New Insights into Freezing of Gait in Parkinson's Disease from Spectral Dynamic Causal Modeling
Seira Taniguchi, Yuta Kajiyama, Takanori Kochiyama, Gajanan Revankar, Kotaro Ogawa, Emi Shirahata, Kana Asai, Chizu Saeki, Tatsuhiko Ozono, Yasuyoshi Kimura, Kensuke Ikenaka, Nicholas D'Cruz, Moran Gilat, Alice Nieuwboer, Hideki Mochizuki
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背景步态冻结是帕金森病(PD)最令人不安的运动症状之一。然而,与步态冻结的病理生理机制相关的关键大脑中枢之间的有效连接性仍然难以确定。结果发现与非冻结者相比,冻结者的双侧背外侧前额叶皮层(DLPFC)和双侧间脑运动区(MLR)之间的功能连接异常增加。随后,频谱 DCM 分析表明,与非冻结者相比,冻结者从左侧 DLPFC 到双侧 MLR 的自上而下的兴奋性有效连接以及左侧 DLPFC 内部的独立自我抑制性连接(99% 后验概率)的增加与步态冻结的严重程度成反比。这些有效连通性模式的侧向性与最初的多巴胺能缺陷无关,也与这些区域的结构变化无关。我们的研究结果表明,通过神经刺激或其他干预措施调节左侧DLPFC和MLR之间的有效连接可能是减少PD步态冻结的一个目标。© 2024 The Author(s).运动障碍》由 Wiley Periodicals LLC 代表国际帕金森和运动障碍协会出版。
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