Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects

Abstract

Neurodegenerative diseases, along with cardiovascular and oncological pathologies, are one of the most acute problems of modern medicine requiring an integrated approach to the study of the molecular mechanisms of their pathogenesis and the search for new targets for the drug treatment. Neuronal calcium signaling deserves close attention of researchers; numerous violations of it have been noted in the study of a number of neurodegenerative pathologies. In this review, we have focused on one of the most common and important ways of calcium influx into the cell, store-operated calcium entry. Here are collected studies demonstrating alterations of the store-operated calcium entry in various neurodegenerative diseases, primarily in Alzheimer’s, Parkinson’s, and Huntington’s diseases, the molecular determinants mediating these disorders are analyzed, and ways of their pharmacological correction are proposed. The information summarized in this review will allow us to look at store-operated channels as one of the most promising targets in the search for new therapeutic agents to treat neurodegenerative pathologies and outline further promising directions of research in this area.