Cell Membrane Cholesterol and Regulation of Cellular Processes: New and the Same Old Thing

IF 1.1 Q4 CELL BIOLOGY Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Pub Date : 2024-09-17 DOI:10.1134/S1990747824700223

A. Ya. Dunina-Barkovskaya

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Abstract

Membranes of living cells, or biological membranes, are unique molecular systems in which the functioning of all molecules is interdependent and coordinated, and disruption of this coordination can be fatal for the cell. One example of such coordination and mutual regulation is the functioning of membrane proteins, whose activity depends on their interaction with membrane lipids. This review summarizes the facts about the importance of the cholesterol component of cell membranes for the normal functioning of membrane proteins and the whole cell. This lipid component provides fine regulation of a variety of cellular functions and provides clues to understanding changes in the activity of a number of proteins under various physiologic and pathologic conditions. This review provides examples of cholesterol-dependent membrane proteins and cellular processes and discusses their role in several pathologies. Understanding the mechanisms of cholesterol–protein interactions represents a significant resource for the development of drugs that affect the cholesterol–protein interface.

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细胞膜胆固醇与细胞过程调控：新旧事物

摘要活细胞的膜或生物膜是一个独特的分子系统，在这个系统中，所有分子的功能都是相互依存和相互协调的，破坏这种协调对细胞来说可能是致命的。这种协调和相互调节的一个例子就是膜蛋白的功能，它们的活性取决于与膜脂质的相互作用。本综述总结了细胞膜中胆固醇成分对膜蛋白和整个细胞正常功能的重要性。这种脂质成分能对多种细胞功能进行精细调节，并为了解多种蛋白质在各种生理和病理条件下的活性变化提供线索。本综述将举例说明胆固醇依赖性膜蛋白和细胞过程，并讨论它们在几种病症中的作用。了解胆固醇-蛋白质相互作用的机制是开发影响胆固醇-蛋白质界面的药物的重要资源。

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来源期刊

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology CELL BIOLOGY-

CiteScore

1.40

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0.00%

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期刊介绍： Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.

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