Fengyuan Liu, Jiashan Xia, Chun Tao, Changmei Chen, Xiangshu Cheng, Rongchun Yi, Lulu Wang, Yue Wang, Tao Deng
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引用次数: 0
Abstract
Chirality is a ubiquitous phenomenon in nature. The advent of nanomaterials has led to a gradual evolution of chiral studies from the molecular scale to the nanoscale. The emergence of carbon dots (CDs) has inaugurated a novel domain in the scientific and technological realms of carbon nanomaterials. In recent years, CDs have attracted increasing attention due to their luminescent properties, excellent biocompatibility and remarkable bioactivity. However, little attention has been paid to the chirality of the CDs and, in particular, the differences between CDs synthesized from racemic compounds and other chiral CDs, as well as the differences in the biological effects of chiral CDs, remain to be explored. Here, chiral CDs were synthesized from L-/D-/DL-arginine, and the differences in various aspects of chiral CDs were evaluated. We found that L-CDs without extreme differences in structure had brighter fluorescence and a more significant ability of NO generation and lipid droplet inhibition than the other two chiral CDs. Combined with its better drug loading and release ability, we validated its superior efficacy in tumor treatment. Therefore, this study provides a basis for further research on chiral carbon dots and their differences.
手性是自然界无处不在的现象。纳米材料的出现使得手性研究逐渐从分子尺度发展到纳米尺度。碳点(CD)的出现为碳纳米材料的科学和技术领域开辟了一个新的领域。近年来,碳点因其发光特性、优异的生物相容性和显著的生物活性而日益受到关注。然而,人们很少关注 CD 的手性,特别是由外消旋化合物合成的 CD 与其他手性 CD 之间的差异,以及手性 CD 在生物效应方面的差异仍有待探索。在此,我们以 L-/D-/DL-精氨酸为原料合成了手性 CD,并评估了手性 CD 各方面的差异。我们发现,与其他两种手性 CD 相比,结构无极大差异的 L-CD 具有更明亮的荧光、更显著的 NO 生成能力和脂滴抑制能力。结合其更好的药物负载和释放能力,我们验证了其在肿瘤治疗中的卓越功效。因此,本研究为进一步研究手性碳点及其差异提供了基础。
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices