{"title":"Exploring enzyme-immobilized MOFs and their application potential: biosensing, biocatalysis, targeted drug delivery and cancer therapy","authors":"Om Prakash, Deepika Verma, Poonam C. Singh","doi":"10.1039/d4tb01556h","DOIUrl":null,"url":null,"abstract":"Enzymes are indispensable in several applications including biosensing and degradation of pollutants and in the drug industry. However, adverse conditions restrict enzymes' utility in biocatalysis due to their inherent limitations. Metal–organic frameworks (MOFs), with their robust structure, offer an innovative avenue for enzyme immobilization, enhancing their resilience against harsh solvents and temperatures. This advancement is pivotal for application in bio-sensing, bio-catalysis, and specifically, targeted drug delivery in cancer therapy, where enzyme–MOF composites enable precise therapeutic localization, minimizing the side effects of traditional treatment. The adaptable nature of MOFs enhances drug biocompatibility and availability, significantly improving therapeutic outcomes. Moreover, the integration of enzyme-immobilized MOFs into bio-sensing represents a leap forward in the rapid and accurate identification of biomarkers, facilitating early diagnosis and disease monitoring. In bio-catalysis, this synergy promotes efficient and environmentally safe chemical synthesis, enhancing reaction rates and yields and broadening the scope of enzyme application in pharmaceutical and bio-fuel production. This review article explores the immobilization techniques and their biomedical applications, specifically focusing on drug delivery in cancer therapy and bio-sensing. Additionally, it addresses the challenges faced in this expanding field.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Chemistry B","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1039/d4tb01556h","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Enzymes are indispensable in several applications including biosensing and degradation of pollutants and in the drug industry. However, adverse conditions restrict enzymes' utility in biocatalysis due to their inherent limitations. Metal–organic frameworks (MOFs), with their robust structure, offer an innovative avenue for enzyme immobilization, enhancing their resilience against harsh solvents and temperatures. This advancement is pivotal for application in bio-sensing, bio-catalysis, and specifically, targeted drug delivery in cancer therapy, where enzyme–MOF composites enable precise therapeutic localization, minimizing the side effects of traditional treatment. The adaptable nature of MOFs enhances drug biocompatibility and availability, significantly improving therapeutic outcomes. Moreover, the integration of enzyme-immobilized MOFs into bio-sensing represents a leap forward in the rapid and accurate identification of biomarkers, facilitating early diagnosis and disease monitoring. In bio-catalysis, this synergy promotes efficient and environmentally safe chemical synthesis, enhancing reaction rates and yields and broadening the scope of enzyme application in pharmaceutical and bio-fuel production. This review article explores the immobilization techniques and their biomedical applications, specifically focusing on drug delivery in cancer therapy and bio-sensing. Additionally, it addresses the challenges faced in this expanding field.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices