The inertial-based gait normalcy index of dual task cost during turning quantifies gait automaticity improvement in early-stage Parkinson’s rehabilitation

IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of NeuroEngineering and Rehabilitation Pub Date : 2024-09-19 DOI:10.1186/s12984-024-01456-0
Lin Meng, Yu Shi, Hongbo Zhao, Deyu Wang, Xiaodong Zhu, Dong Ming
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Abstract

The loss of gait automaticity is a key cause of motor deficits in Parkinson’s disease (PD) patients, even at the early stage of the disease. Action observation training (AOT) shows promise in enhancing gait automaticity. However, effective assessment methods are lacking. We aimed to propose a novel gait normalcy index based on dual task cost (NIDTC) and evaluate its validity and responsiveness for early-stage PD rehabilitation. Thirty early-stage PD patients were recruited and randomly assigned to the AOT or active control (CON) group. The proposed NIDTC during straight walking and turning tasks and clinical scale scores were measured before and after 12 weeks of rehabilitation. The correlations between the NIDTCs and clinical scores were analyzed with Pearson correlation coefficient analysis to evaluate the construct validity. The rehabilitative changes were assessed using repeated-measures ANOVA, while the responsiveness of NIDTC was further compared by t tests. The turning-based NIDTC was significantly correlated with multiple clinical scales. Significant group-time interactions were observed for the turning-based NIDTC (F = 4.669, p = 0.042), BBS (F = 6.050, p = 0.022) and PDQ-39 (F = 7.772, p = 0.011) tests. The turning-based NIDTC reflected different rehabilitation effects between the AOT and CON groups, with the largest effect size (p = 0.020, Cohen’s d = 0.933). The turning-based NIDTC exhibited the highest responsiveness for identifying gait automaticity improvement by providing a comprehensive representation of motor ability during dual tasks. It has great potential as a valid measure for early-stage PD diagnosis and rehabilitation assessment. Trial registration Chinese Clinical Trial Registry: ChiCTR2300067657
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基于惯性的步态正常指数(转弯时的双重任务成本)可量化帕金森病早期康复中步态自动性的改善情况
步态自动性的丧失是帕金森病(PD)患者运动障碍的主要原因,即使在疾病的早期阶段也是如此。动作观察训练(AOT)有望增强步态的自动性。然而,目前还缺乏有效的评估方法。我们旨在提出一种基于双重任务成本的新型步态正常指数(NIDTC),并评估其在早期帕金森病康复中的有效性和响应性。我们招募了 30 名早期帕金森病患者,并将他们随机分配到 AOT 组或主动对照组(CON)。在康复训练 12 周前和 12 周后,测量了直行和转身任务中的 NIDTC 和临床量表评分。采用皮尔逊相关系数分析法对 NIDTC 和临床评分之间的相关性进行分析,以评估构建有效性。采用重复测量方差分析评估康复变化,并通过 t 检验进一步比较 NIDTC 的反应性。以翻身为基础的 NIDTC 与多个临床量表有明显的相关性。在以翻身为基础的 NIDTC(F = 4.669,p = 0.042)、BBS(F = 6.050,p = 0.022)和 PDQ-39 (F = 7.772,p = 0.011)测试中,观察到了明显的组间交互作用。以翻身为基础的 NIDTC 反映了 AOT 组和 CON 组之间不同的康复效果,其效应大小最大(p = 0.020,Cohen's d = 0.933)。通过全面反映双重任务中的运动能力,基于转弯的 NIDTC 在识别步态自动性改善方面表现出最高的响应性。它作为早期帕金森病诊断和康复评估的有效测量指标具有很大的潜力。试验注册:中国临床试验注册中心:ChiCTR2300067657
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation 工程技术-工程:生物医学
CiteScore
9.60
自引率
3.90%
发文量
122
审稿时长
24 months
期刊介绍: Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
期刊最新文献
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