Summary of Research: Dapagliflozin Utilization in Chronic Kidney Disease and Its Real-World Effectiveness Among Patients with Lower Levels of Albuminuria in the USA and Japan

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Advances in Therapy Pub Date : 2024-09-19 DOI:10.1007/s12325-024-02961-3

Navdeep Tangri, Anjay Rastogi, Tadashi Sofue

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Abstract

This is a summary of the original article ‘Dapagliflozin Utilization in Chronic Kidney Disease and Its Real-World Effectiveness Among Patients with Lower Levels of Albuminuria in the USA and Japan’. The slowing down of kidney function decline is important for managing chronic kidney disease (CKD) and preventing its complications. Clinical trials of dapagliflozin, a sodium–glucose cotransporter-2 inhibitor (SGLT-2i), have shown reductions in disease progression and death in patients with CKD and elevated levels of albuminuria. This summary of research provides an overview of a previously published article that aimed to find out whether dapagliflozin is also effective in patients with lower levels of albuminuria [urinary albumin-to-creatinine ratio (UACR) below 200 mg/g]. Starting dapagliflozin was associated with slower kidney function decline in patients with CKD and UACR below 200 mg/g compared with not starting. This effect was also observed in a subgroup analysis of patients without type 2 diabetes. These results suggest that the established benefits of SGLT-2is may extend to patients with lower levels of albuminuria.

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研究摘要：美国和日本白蛋白尿水平较低的慢性肾病患者使用达帕格列净的情况及其实际疗效

本文是原文《美国和日本白蛋白尿水平较低患者在慢性肾脏病中使用达帕格列净的情况及其实际疗效》的摘要。减缓肾功能衰退对于控制慢性肾脏病（CKD）和预防其并发症非常重要。钠-葡萄糖共转运体-2抑制剂（SGLT-2i）达帕格列净的临床试验显示，它能减少慢性肾脏病和白蛋白尿水平升高患者的疾病进展和死亡。本研究摘要概述了之前发表的一篇文章，该文章旨在了解达帕格列净是否对白蛋白尿水平较低[尿白蛋白与肌酐比值（UACR）低于200毫克/克]的患者也有效。与不开始服用达帕格列净相比，开始服用达帕格列净会减缓慢性肾脏病患者的肾功能衰退，且 UACR 低于 200 毫克/克。在对无 2 型糖尿病患者进行的亚组分析中也观察到了这种效应。这些结果表明，SGLT-2is 既定的益处可能会扩展到白蛋白尿水平较低的患者。

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来源期刊

Advances in Therapy 医学-药学

CiteScore

7.20

自引率

2.60%

发文量

353

审稿时长

6-12 weeks

期刊介绍： Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.