Highly Effective DPA-SCP Sonosensitizer for Biofilm Removal in Infected Root Canals via Sonodynamic Therapy

Abstract

Chemical debridement constitutes a pivotal phase in eradicating microbial entities during endodontic therapy. The antimicrobial efficacy of endodontic irrigants in clinical use is contingent upon their concentration; however, elevated concentrations engender significant risk to tissue integrity. Consequently, we advocate for an innovative and benign sonodynamic antimicrobial approach. This method employs the sonosensitizer DPA-SCP, which, under the influence of low-frequency ultrasonic waves, catalyzes the generation of copious reactive oxygen species (ROS). Empirical evaluations indicate that DPA-SCP demonstrates a robust antibacterial capacity towards E. faecalis suspensions and biofilms established on the internal surfaces of root canals. Moreover, its bactericidal impact is comparable to the use of 5.25% sodium hypochlorite. Moreover, DPA-SCP demonstrates markedly reduced cytotoxicity towards fibroblasts relative to conventional endodontic irrigants, and the thermal elevation induced by ultrasonic application remains within non-detrimental limits. This sonodynamic disinfection paradigm presents a valuable and prospective clinical application in endodontic sanitation.