Rare features of giant cell tumors of the bone: A case report.

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Experimental and therapeutic medicine Pub Date : 2024-08-28 DOI:10.3892/etm.2024.12698
Chao Wang,Ying Guo,Lu Wang,Zunzhen Nie,Jin Zhu,Qingguo Yan
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Abstract

Giant cell tumors of the bone are local invasive diseases that are mainly composed of neoplastic monocytes and nonneoplastic multinucleated giant cells, mostly in the long bones of patients with mature bones. A specific H3F3A mutation is the key to its diagnosis. The present paper reports a case of giant cell tumor of the bone (GCTB) characterized by diffuse cholesterol crystals with few multinucleated giant cells. Imaging examination combined with immunohistochemical H3.3 G34W positivity was used to diagnose the patient with GCTB. Understanding the unique histological morphology of this patient will help doctors correctly diagnose giant cell tumors of bone and avoid misdiagnosis.
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骨巨细胞瘤的罕见特征:病例报告。
骨巨细胞瘤是一种局部侵袭性疾病,主要由肿瘤性单核细胞和非肿瘤性多核巨细胞组成,多发于骨骼发育成熟的患者的长骨中。特异性 H3F3A 突变是诊断的关键。本文报告了一例骨巨细胞瘤(GCTB)病例,其特征是弥漫性胆固醇结晶和少量多核巨细胞。影像学检查结合免疫组化 H3.3 G34W 阳性可诊断该患者为骨巨细胞瘤。了解该患者独特的组织学形态有助于医生正确诊断骨巨细胞瘤,避免误诊。
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来源期刊
Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
期刊介绍:
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