{"title":"RAD50 is a potential biomarker for breast cancer diagnosis and prognosis","authors":"Kunwer S. Chhatwal, Hengrui Liu","doi":"10.1101/2024.09.07.611821","DOIUrl":null,"url":null,"abstract":"BACKGROUND: RAD50 is one of the most critical genes in DNA double-strand break processing, which can lead to a single strand of DNA overhang and is potentially involved in forcing incomplete DNA repair. This research study aims to investigate the role of RAD50 in breast cancer diagnosis and prognosis. METHODS: Breast cancer mRNA expression data was collected from TCGA and the difference between cancer and non-cancer in gene expression of RAD50 was analyzed. The survival association of RAD50 was also analyzed. RESULTS: RAD50 expression is significantly lower in cancer than in normal tissue. High expression of RAD50 is associated with worse survival. Conclusion: RAD50 is a potential biomarker for breast cancer diagnosis and prognosis","PeriodicalId":501233,"journal":{"name":"bioRxiv - Cancer Biology","volume":"50 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Cancer Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.07.611821","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
BACKGROUND: RAD50 is one of the most critical genes in DNA double-strand break processing, which can lead to a single strand of DNA overhang and is potentially involved in forcing incomplete DNA repair. This research study aims to investigate the role of RAD50 in breast cancer diagnosis and prognosis. METHODS: Breast cancer mRNA expression data was collected from TCGA and the difference between cancer and non-cancer in gene expression of RAD50 was analyzed. The survival association of RAD50 was also analyzed. RESULTS: RAD50 expression is significantly lower in cancer than in normal tissue. High expression of RAD50 is associated with worse survival. Conclusion: RAD50 is a potential biomarker for breast cancer diagnosis and prognosis
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