Effect of reaction time on the properties of poly(xylitol sebacate) for nanoparticle formation

IF 2.6 4区化学 Q3 POLYMER SCIENCE Journal of Polymer Research Pub Date : 2024-09-17 DOI:10.1007/s10965-024-04114-0

Kadisha M. Culpepper, Jasmin B. Tindal, Natalie Y. Arnett

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Abstract

This research aims to correlate poly(xylitol sebacate) (PXS) nanoparticle formation via nanoprecipitation in the presence of Pluronic® F-127 to changes in polymer reaction times. PXS is successfully synthesized using xylitol and sebacic acid via melt polymerization (MP) at 10, 15 and 20 h. ¹H-NMR and ¹³C-NMR confirmed the successful formation of PXS branched structures by the conversion of hydroxyl groups to acyl groups and ester bond formation in two different environments. The degree of branching and gel fraction increased with longer reaction time, which resulted in the crosslinking of PXS-MP-20H, deeming it insoluble for nanoparticle formation. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability up to ~ 200 °C and an amorphous nature with subambient glass transition temperatures (T_g). Among all polyesters, PXS-MP-15H showed best and only nanoparticle formation with average diameter size ranging from 112 to 132 nm for curcumin-loaded and unloaded respectively confirmed using dynamic light scattering (DLS). PXS-MP-15H nanoparticles had a curcumin encapsulation efficiency of 23.9%. This study shows the potential of highly branched polyesters such as PXS for use as drug carriers for targeted delivery.

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反应时间对聚(木糖醇癸二酸酯)纳米粒子形成性能的影响

本研究旨在将在 Pluronic® F-127 存在下通过纳米沉淀形成的聚（木糖醇癸二酸酯）（PXS）纳米粒子与聚合物反应时间的变化联系起来。1H-NMR 和 13C-NMR 证实，在两种不同的环境中，通过羟基向酰基的转化和酯键的形成，成功地形成了 PXS 支化结构。支化程度和凝胶部分随着反应时间的延长而增加，这导致了 PXS-MP-20H 的交联，使其不溶于纳米颗粒的形成。热重分析（TGA）和差示扫描量热仪（DSC）证实，PXS-MP-20H 的热稳定性可高达约 200 °C，并且具有亚环境玻璃化转变温度（Tg）的无定形性质。在所有聚酯中，PXS-MP-15H 显示出最佳且唯一的纳米粒子形成，用动态光散射（DLS）法证实，姜黄素负载和未负载纳米粒子的平均直径尺寸范围分别为 112 至 132 nm。PXS-MP-15H 纳米粒子的姜黄素封装效率为 23.9%。这项研究显示了 PXS 等高支化聚酯作为药物载体用于靶向递送的潜力。

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来源期刊

Journal of Polymer Research 化学-高分子科学

CiteScore

4.70

自引率

7.10%

发文量

472

审稿时长

3.6 months

期刊介绍： Journal of Polymer Research provides a forum for the prompt publication of articles concerning the fundamental and applied research of polymers. Its great feature lies in the diversity of content which it encompasses, drawing together results from all aspects of polymer science and technology. As polymer research is rapidly growing around the globe, the aim of this journal is to establish itself as a significant information tool not only for the international polymer researchers in academia but also for those working in industry. The scope of the journal covers a wide range of the highly interdisciplinary field of polymer science and technology, including: polymer synthesis; polymer reactions; polymerization kinetics; polymer physics; morphology; structure-property relationships; polymer analysis and characterization; physical and mechanical properties; electrical and optical properties; polymer processing and rheology; application of polymers; supramolecular science of polymers; polymer composites.