Zhu Liduzi Jiesisibieke, Io Ieong Chan, Jack Chun Man Ng, C Mary Schooling
{"title":"A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass Index","authors":"Zhu Liduzi Jiesisibieke, Io Ieong Chan, Jack Chun Man Ng, C Mary Schooling","doi":"10.1101/2024.09.12.24313524","DOIUrl":null,"url":null,"abstract":"<strong>Background: </strong>Trials of incretins are making it increasingly clear that body mass index (BMI) is linked to several diseases throughout life, but trials cannot provide a comprehensive assessment of the role of BMI in health-related attributes for men and women. To systematically investigate the role of BMI, we conducted a sex-specific Mendelian randomization-phenome-wide association study.","PeriodicalId":501071,"journal":{"name":"medRxiv - Epidemiology","volume":"75 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.12.24313524","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Trials of incretins are making it increasingly clear that body mass index (BMI) is linked to several diseases throughout life, but trials cannot provide a comprehensive assessment of the role of BMI in health-related attributes for men and women. To systematically investigate the role of BMI, we conducted a sex-specific Mendelian randomization-phenome-wide association study.