Impaired somatosensory habituation in older adults with chronic pain during an affective oddball task

IF 3.5 2区 医学 Q1 ANESTHESIOLOGY European Journal of Pain Pub Date : 2024-09-18 DOI:10.1002/ejp.4732
Alejandro Dorado, Carolina Sitges, Marian van der Meulen, Ana M. González‐Roldán
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Abstract

BackgroundChronic pain is one of the most common health conditions among older adults, triggering various disruptions in information processing across attentional, emotional, and somatosensory domains. However, there is insufficient information about how these aspects interact and their potential contribution to the vulnerability of older adults to chronic pain. This study aimed to investigate potential alterations induced by chronic pain during aging in attentional aspects of tactile stimulation and to observe the influence of affective context.MethodTwenty‐six older adults with chronic pain (70.00 ± 5.07 years; 11 males), 28 pain‐free older adults (69.57 ± 3.96 years; 13 males) and 27 healthy younger adults (21.48 ± 1.80 years; 14 males) participated in the study. We compared the somatosensory evoked potentials elicited by frequent and deviant stimulation (probability 14%) applied when participants were viewing blocks of pleasant, unpleasant, and neutral images from the International Affective Picture System.ResultsDuring frequent stimulation, older adults with chronic pain showed higher P50 and N100 amplitudes compared to pain‐free older adults and younger individuals. Furthermore, the older group with pain exhibited higher P300 amplitude during emotional contexts compared to neutral scenarios. During deviant stimulation, older adults with chronic pain exhibited higher P50 and N100 amplitudes compared to pain‐free older adults but displayed typical age‐related flattening during P300.ConclusionsThese findings indicate that chronic pain leads to a decline in the ability to habituate to non‐painful irrelevant somatosensory stimuli, especially when it is presented in an emotional context.Significance StatementIn the present study, we have observed how older individuals suffering from chronic pain exhibit a decline in the habituation capacity of irrelevant somatosensory information. Furthermore, we have observed how the affective context in which these individuals are situated leads to an exacerbation of this deficit. Enhancing our comprehension of how aging and chronic pain interact to impact somatosensory processing could facilitate the tailoring of novel intervention strategies.
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患有慢性疼痛的老年人在进行情感怪球任务时的体感习惯性受损
背景慢性疼痛是老年人最常见的健康问题之一,会引发注意力、情绪和体感领域信息处理的各种紊乱。然而,关于这些方面如何相互作用以及它们对老年人易受慢性疼痛影响的潜在作用,目前还没有足够的信息。本研究旨在调查慢性疼痛在衰老过程中可能诱发的触觉刺激注意力方面的变化,并观察情感环境的影响。方法26名患有慢性疼痛的老年人(70.00 ± 5.07岁;11名男性)、28名无痛老年人(69.57 ± 3.96岁;13名男性)和27名健康的年轻成年人(21.48 ± 1.80岁;14名男性)参与了本研究。我们比较了当参与者观看国际情感图像系统中的愉快、不愉快和中性图像块时,频繁刺激和偏差刺激(概率为 14%)所引起的体感诱发电位。此外,与中性情景相比,患有疼痛的老年人组在情绪情景中表现出更高的 P300 振幅。这些研究结果表明,慢性疼痛会导致对非疼痛性无关躯体感觉刺激的习惯化能力下降,尤其是当这些刺激出现在情绪化情境中时。此外,我们还观察到这些人所处的情感环境是如何导致这种缺陷加剧的。加强我们对衰老和慢性疼痛如何相互作用影响躯体感觉处理的理解,有助于定制新的干预策略。
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来源期刊
European Journal of Pain
European Journal of Pain 医学-临床神经学
CiteScore
7.50
自引率
5.60%
发文量
163
审稿时长
4-8 weeks
期刊介绍: European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.
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