The regulatory mechanism of natural polysaccharides in type 2 diabetes mellitus treatment

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY Drug Discovery Today Pub Date : 2024-09-14 DOI:10.1016/j.drudis.2024.104182

Surina Bo , Mu Dan , Wei Li , Chen Chen

{"title":"The regulatory mechanism of natural polysaccharides in type 2 diabetes mellitus treatment","authors":"Surina Bo , Mu Dan , Wei Li , Chen Chen","doi":"10.1016/j.drudis.2024.104182","DOIUrl":null,"url":null,"abstract":"<div><div>Diabetes is a complex, multifactorial disease that is caused by a pathological combination of insulin resistance and pancreatic islet dysfunction. Polysaccharides are extensively dispersed in nature and have a very complicated structure with various biological properties. Natural polysaccharides have potentially extraordinary beneficial health effects on managing metabolic diseases such as diabetes, obesity and cardiovascular disease. Thus, a systematic review of the latest research into and possible regulatory mechanisms of natural polysaccharides for type 2 diabetes mellitus treatment is of great significance for a better understanding of their pharmaceutical value. We discuss the regulatory mechanisms of natural polysaccharides for the treatment of diabetes, and especially their role in reshaping dysfunctional gut microbiota. Natural polysaccharides could be developed as new and safe antidiabetic drugs, and detailed mechanistic studies could further clarify the molecular targets of polysaccharides in the treatment of diabetes.</div></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"29 11","pages":"Article 104182"},"PeriodicalIF":6.5000,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1359644624003076/pdfft?md5=0e0518270b681b81f1885e4f5c0b10f9&pid=1-s2.0-S1359644624003076-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359644624003076","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Diabetes is a complex, multifactorial disease that is caused by a pathological combination of insulin resistance and pancreatic islet dysfunction. Polysaccharides are extensively dispersed in nature and have a very complicated structure with various biological properties. Natural polysaccharides have potentially extraordinary beneficial health effects on managing metabolic diseases such as diabetes, obesity and cardiovascular disease. Thus, a systematic review of the latest research into and possible regulatory mechanisms of natural polysaccharides for type 2 diabetes mellitus treatment is of great significance for a better understanding of their pharmaceutical value. We discuss the regulatory mechanisms of natural polysaccharides for the treatment of diabetes, and especially their role in reshaping dysfunctional gut microbiota. Natural polysaccharides could be developed as new and safe antidiabetic drugs, and detailed mechanistic studies could further clarify the molecular targets of polysaccharides in the treatment of diabetes.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

天然多糖在 2 型糖尿病治疗中的调节机制

糖尿病是一种复杂的多因素疾病，由胰岛素抵抗和胰岛功能障碍的病理组合引起。多糖广泛分布于自然界中，具有非常复杂的结构和各种生物特性。天然多糖对控制糖尿病、肥胖症和心血管疾病等代谢性疾病具有非凡的潜在保健作用。因此，对天然多糖治疗 2 型糖尿病的最新研究和可能的调控机制进行系统综述，对于更好地了解天然多糖的医药价值具有重要意义。我们讨论了天然多糖治疗糖尿病的调节机制，特别是其在重塑功能失调的肠道微生物群方面的作用。天然多糖可开发为安全的新型抗糖尿病药物，详细的机理研究可进一步阐明多糖治疗糖尿病的分子靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.