Divergent effects of acute and chronic PPT1 inhibition in melanoma

IF 14.6 1区 生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2024-09-12 DOI:10.1080/15548627.2024.2403152
Mary Ann S. Crissey, Amanda Versace, Monika Bhardwaj, Vaibhav Jain, Shujing Liu, Arpana Singh, Lynn A. Beer, Hsin-Yao Tang, Jessie Villanueva, Phyllis A. Gimotty, Xiaowei Xu, Ravi K. Amaravadi
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引用次数: 0

Abstract

Macroautophagy/autophagy-lysosome function promotes growth and survival of cancer cells, making them attractive targets for cancer therapy. One intriguing lysosomal target is PPT1 (palmitoyl-protei...
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急性和慢性 PPT1 抑制对黑色素瘤的不同影响
大自噬/自噬-溶酶体功能可促进癌细胞的生长和存活,因此成为癌症治疗的诱人靶点。一个令人感兴趣的溶酶体靶点是PPT1(棕榈酰蛋白酶)。
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来源期刊
Autophagy
Autophagy 生物-细胞生物学
CiteScore
21.30
自引率
2.30%
发文量
277
审稿时长
1 months
期刊介绍: Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.
期刊最新文献
Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis. Burkholderia pseudomallei BipD initiates mitophagy to evade killing by hijacking host KLHL9-KLHL13-CUL3 E3 ligase to ubiquitinate IMMT The interplay between probiotics and host autophagy: mechanisms of action and emerging insights. Divergent effects of acute and chronic PPT1 inhibition in melanoma The autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) suppresses anorexia
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