Modeling the Kinetics of Drug Desorption from a Tablet Based on a Polymer Matrix

IF 0.58 Q4 Materials Science Polymer Science, Series D Pub Date : 2024-09-19 DOI:10.1134/S1995421224701144
N. V. Chernousova, V. A. Zakharova, A. V. Dedov
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Abstract

Using literature data, a model was developed to predict the kinetics of drug’ desorption from hydroxypropyl-methylcellulose-based tablets at different water stirring rates. When the tablet comes into contact with a gastric juice, the polymer swells to form a gel-like shell, which prevents the transfer of gastric juice into the tablet and determines the rate of drug release into the human body. We used an equation that describes the kinetic dependences of drug desorption in the coordinate system of a conditional time equal to the square root of the observation time. Dependence of the equation coefficients on the stirring speed was established, which made it possible to obtain a model for predicting the kinetics of drug desorption from the time of contact with water and the water stirring speed.

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基于聚合物基质的片剂药物解吸动力学建模
摘要 利用文献数据建立了一个模型,用于预测不同水搅拌速率下羟丙基甲基纤维素片剂的药物解吸动力学。当片剂与胃液接触时,聚合物会膨胀形成凝胶状外壳,从而阻止胃液转移到片剂中,并决定药物释放到人体内的速度。我们使用了一个方程,该方程描述了在条件时间等于观察时间平方根的坐标系中药物解吸的动力学相关性。方程系数与搅拌速度的关系已经确定,这使得从与水接触的时间和水搅拌速度预测药物解吸动力学的模型成为可能。
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来源期刊
Polymer Science, Series D
Polymer Science, Series D Materials Science-Polymers and Plastics
CiteScore
0.80
自引率
0.00%
发文量
87
期刊介绍: Polymer Science, Series D  publishes useful description of engineering developments that are related to the preparation and application of glues, compounds, sealing materials, and binding agents, articles on the adhesion theory, prediction of the strength of adhesive joints, methods for the control of their properties, synthesis, and methods of structural modeling of glued joints and constructions, original articles with new scientific results, analytical reviews of the modern state in the field.
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