Arylation of 2-Chloro-3-(4,6-Diaryl-1,3,5-Triazin-2-yl) Quinolines: Formal Synthesis of 3-(4,6-Diaryl-1,3,5-Triazin-2-yl)-2-Substituted Quinolines by Suzuki–Miyaura Reaction

Abstract

We have described herein a simple and formal two-step synthesis of 3-(4,6-diaryl-1,3,5-triazin-2-yl)-2-aryl quinolines from 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines and boronic acids under the Suzuki–Miyaura conditions. This protocol provides the C-2 arylation of 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines under the mild reaction conditions. These newly formed chemo-types may be useful in drug discovery programs or in material chemistry.