Cytopathological findings of granular cell glioblastoma in intraoperative squash smear preparations: A case report

Abstract

Granular cell glioblastoma is a rare subtype of IDH-wildtype glioblastoma, which may mimic benign macrophage-rich brain lesions during intraoperative consultation. Few studies have previously discussed its cytopathological features with special attention to the differential diagnosis during intraoperative consultation. After a comparative analysis of previously reported cases, we found that some cytopathological findings can be useful to differentiate granular tumour cells from macrophages and other central nervous system tumours, although their presentation is not constant and clinical and radiological correlation is always critical.