Ethical issues in organ procurement: donation after normothermic regional perfusion in liver transplantation.

IF 1.8 4区 医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2024-09-20 DOI:10.1097/mot.0000000000001174
Brian M Nguyen
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Abstract

PURPOSE OF REVIEW With ongoing organ shortages, new perfusion technologies are being embraced to help fill the unmet requirement. Improvement in utilization of donation after cardiac death (DCD) donors has the potential to greatly expand the pool of usable liver allografts. Normothermic regional perfusion (NRP) has been shown to increase usage of DCD donors and improve recipient outcomes. Yet, there remains heterogeneity in its usage worldwide. RECENT FINDINGS Results from the first US multicenter study show improved biliary outcomes with NRP, consistent with prior data from Europe. Internationally, there are wide variations in DCD and NRP usage, highlighting the opportunities for improvement and increased utilization. The ethics of this technique continue to be considered. SUMMARY NRP is a sound technique that can improve utilization for DCD donors, thereby increasing organ supply. Its usage is increasing worldwide. New data continue to show the benefit of this procurement strategy. NRP agrees with the principles of ethics.
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器官获取中的伦理问题:肝脏移植中常温区域灌注后的捐赠。
综述目的随着器官短缺问题的持续存在,新的灌注技术正在被广泛应用,以帮助满足未得到满足的需求。提高心脏死亡后捐献(DCD)供体的利用率有可能大大增加可用肝脏同种异体移植的数量。常温区域灌注(NRP)已被证明能提高心脏死亡后捐献者的利用率并改善受者的预后。美国第一项多中心研究结果显示,NRP可改善胆道预后,这与欧洲之前的数据一致。在全球范围内,DCD 和 NRP 的使用情况差异很大,这凸显了改进和提高使用率的机会。总结NRP是一项完善的技术,可以提高DCD捐献者的利用率,从而增加器官供应。其使用率在全球范围内不断增加。新的数据不断显示出这种获取策略的益处。NRP 符合伦理原则。
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来源期刊
CiteScore
4.10
自引率
4.50%
发文量
124
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.
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