Psoriasis treatment and biologic switching: The association with clinical characteristics and laboratory biomarkers over a 13‐year retrospective study

Asumi Koyama, Lixin Li, Toyoki Yamamoto, Haruka Taira, Eiki Sugimoto, Yukiko Ito, Yuka Mizuno, Kentaro Awaji, Shoko Tateishi, Hiroko Kanda, Shinichi Sato, Sayaka Shibata
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Abstract

The advent of biologics has greatly improved patient outcomes, yet some patients are compelled to switch therapies. Predicting these therapeutic failures is important; however, the factors associated with switching biologics have not been fully explored. This study examined patterns and determinants of biologics switching in psoriasis treatment retrospectively over 13 years. We focused on the association between clinical characteristics, basal laboratory data, and frequency of biologics switching. The findings revealed that elevated Psoriasis Area Severity Index scores and the presence of arthritis were observed in patients who experienced two or more treatment switches compared with those without treatment switches. Moreover, neutrophil to lymphocyte ratio was associated with higher biologics switching rates, indicating that systemic inflammation significantly impacts treatment adherence. A treatment approach, taking into account both the clinical presentation and inflammatory biomarkers, may be important for optimizing patient management in psoriasis.
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银屑病治疗与生物制剂转换:13 年回顾性研究与临床特征和实验室生物标志物的关系
生物制剂的出现大大改善了患者的治疗效果,但有些患者不得不更换疗法。预测这些治疗失败非常重要;然而,与转换生物制剂相关的因素尚未得到充分探讨。本研究回顾性研究了 13 年来银屑病治疗中生物制剂转换的模式和决定因素。我们重点研究了临床特征、基础实验室数据和生物制剂转换频率之间的关联。研究结果表明,与未更换治疗方案的患者相比,更换过两次或两次以上治疗方案的患者的银屑病面积严重性指数评分升高,并伴有关节炎。此外,中性粒细胞与淋巴细胞比率与较高的生物制剂转换率相关,表明全身炎症对治疗依从性有重大影响。同时考虑临床表现和炎症生物标志物的治疗方法可能对优化银屑病患者的管理非常重要。
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