John Kuruvilla, Christopher Rushton, Diego Villa, Muhammad Aslam, Anca Prica, Nizar Abdel Samad, Stephane Doucet, Jill Dudebout, Isabelle Fleury, Graeme Fraser, Jean-Francois Larouche, Mona Shafey, Pamela Skrabek, Tanya Skamene, Ryan D. Morin, Miguel Alcaide, Susana Ben-Neriah, David Lee, Chad Winch, Lois E. Shepherd, David W. Scott, Michael Crump, Bingshu E. Chen, Annette E. Hay
{"title":"A randomized trial of ibrutinib and R-GDP prior to stem cell transplant in relapsed diffuse large B-cell lymphoma","authors":"John Kuruvilla, Christopher Rushton, Diego Villa, Muhammad Aslam, Anca Prica, Nizar Abdel Samad, Stephane Doucet, Jill Dudebout, Isabelle Fleury, Graeme Fraser, Jean-Francois Larouche, Mona Shafey, Pamela Skrabek, Tanya Skamene, Ryan D. Morin, Miguel Alcaide, Susana Ben-Neriah, David Lee, Chad Winch, Lois E. Shepherd, David W. Scott, Michael Crump, Bingshu E. Chen, Annette E. Hay","doi":"10.1111/bjh.19764","DOIUrl":null,"url":null,"abstract":"<p>In the LY.17 randomized phase II clinical trial, adults with relapsed and refractory diffuse large B-cell lymphoma treated with ibrutinib-R-GDP (IR-GDP) for up to three cycles had more documented bacterial and fungal infections, without improvement in overall response, compared with R-GDP. CR, complete response; DLBCL, diffuse large B-cell lymphoma; PD, progressive disease; PR, partial response; R/R, relapsed/refractory; SD, stable disease.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":"205 5","pages":"2067-2071"},"PeriodicalIF":3.8000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Haematology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/bjh.19764","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In the LY.17 randomized phase II clinical trial, adults with relapsed and refractory diffuse large B-cell lymphoma treated with ibrutinib-R-GDP (IR-GDP) for up to three cycles had more documented bacterial and fungal infections, without improvement in overall response, compared with R-GDP. CR, complete response; DLBCL, diffuse large B-cell lymphoma; PD, progressive disease; PR, partial response; R/R, relapsed/refractory; SD, stable disease.
期刊介绍：
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
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