The expanding landscape of canonical and non-canonical protein phosphorylation.

IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2024-09-11 DOI:10.1016/j.tibs.2024.08.004
Thibault Houles,Sang-Oh Yoon,Philippe P Roux
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Abstract

Protein phosphorylation is a crucial regulatory mechanism in cell signaling, acting as a molecular switch that modulates protein function. Catalyzed by protein kinases and reversed by phosphoprotein phosphatases, it is essential in both normal physiological and pathological states. Recent advances have uncovered a vast and intricate landscape of protein phosphorylation that include histidine phosphorylation and more unconventional events, such as pyrophosphorylation and polyphosphorylation. Many questions remain about the true size of the phosphoproteome and, more importantly, its site-specific functional relevance. The involvement of unconventional actors such as pseudokinases and pseudophosphatases adds further complexity to be resolved. This review explores recent discoveries and ongoing challenges, highlighting the need for continued research to fully elucidate the roles and regulation of protein phosphorylation.
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规范和非规范蛋白质磷酸化的不断扩展。
蛋白质磷酸化是细胞信号传导过程中的重要调节机制,是调节蛋白质功能的分子开关。它由蛋白激酶催化,由磷蛋白磷酸酶逆转,在正常生理和病理状态下都至关重要。最近的研究进展揭示了蛋白质磷酸化错综复杂的巨大格局,其中包括组氨酸磷酸化和更多非常规事件,如焦磷酸化和多磷酸化。关于磷酸化蛋白质组的真正规模,更重要的是其特定位点的功能相关性,仍存在许多问题。假激酶和假磷酸酶等非常规参与者的参与进一步增加了有待解决的复杂性。这篇综述探讨了最近的发现和正在面临的挑战,强调了继续研究以全面阐明蛋白质磷酸化的作用和调控的必要性。
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来源期刊
Trends in Biochemical Sciences
Trends in Biochemical Sciences 生物-生化与分子生物学
CiteScore
22.90
自引率
0.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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