Nano-Structured Gel Materials for Environmental Remediation and Biomedical Applications

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Nano Materials Pub Date : 2024-09-19 DOI:10.1021/acsanm.4c04684

Ritik, Sayantan Sarkar, Pragti, Nidhi Varshney, Amardeep Kumar, Maxim L. Kuznetsov, Hem Chandra Jha, Suman Mukhopadhyay

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Abstract

The application of soft materials, including gels, in different material and biological chemistry domains has gained momentum in the past few years. Environmental remediation, drug resistance, and delivery are significant concerns that are being investigated widely nowadays. In this work, we report the multifunctionality of a gelator molecule A2 (5,5′-((6-(phenylamino)-1,3,5-triazine-2,4-diyl)bis(azanediyl))diisophthalic acid) in the gel state. The gelator molecule A2 was used to fabricate organogel and two metallogels using copper perchlorate and a Ru-based anticancer drug molecule, respectively. The organogel and Cu-metallogel show efficient adsorption capabilities of iodine in the vapor and solution phases. These iodine-loaded gel composites were utilized as efficient antibacterial agents against Escherichia coli and Helicobacter pylori (I10) bacterial strains. Additionally, owing to the pH-responsive nature of the gel material, the Ru-based anticancer drug-loaded metallogel, Ru-A2, was fabricated, and its activity in pH-responsive drug delivery to the cancerous cells was also investigated.

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用于环境修复和生物医学应用的纳米结构凝胶材料

在过去几年里，软材料（包括凝胶）在不同材料和生物化学领域的应用势头迅猛。环境修复、抗药性和递送是目前正在广泛研究的重要问题。在这项工作中，我们报告了凝胶分子 A2（5,5′-((6-(苯基氨基)-1,3,5-三嗪-2,4-二基)双（偶氮二基））二间苯二甲酸）在凝胶状态下的多功能性。凝胶剂分子 A2 被用于制造有机凝胶和两种金属凝胶，分别使用高氯酸铜和一种基于 Ru 的抗癌药物分子。有机凝胶和铜金属凝胶显示出在气相和溶液相中对碘的高效吸附能力。这些碘负载凝胶复合材料被用作高效的抗菌剂，可抗击大肠杆菌和幽门螺旋杆菌（I10）菌株。此外，由于凝胶材料的 pH 响应特性，还制备了基于 Ru 的抗癌药物负载金属凝胶 Ru-A2，并研究了其在 pH 响应性向癌细胞递送药物方面的活性。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.