Rapid wideband characterization of viscoelastic material properties by Bessel function-based time harmonic ultrasound elastography (B-THE)

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-09-16 DOI:10.1016/j.jmbbm.2024.106746

Tom Meyer , Matthias Anders , Anton Z. Pietzcker , Marvin Doyley , Steffen Görner , Oliver Böhm , Pascal Engl , Yasmine Safraou , Jürgen Braun , Ingolf Sack , Heiko Tzschätzsch

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Abstract

Elastography is an emerging diagnostic technique that uses conventional imaging modalities such as sonography or magnetic resonance imaging to quantify tissue stiffness. However, different elastography methods provide different stiffness values, which require calibration using well-characterized phantoms or tissue samples. A comprehensive, fast, and cost-effective elastography technique for phantoms or tissue samples is still lacking.

Therefore, we propose ultrasound Bessel-fit-based time harmonic elastography (B-THE) as a novel tool to provide rapid feedback on stiffness-related shear wave speed (SWS) and viscosity-related wave penetration rate (PR) over a wide range of harmonic vibration frequencies. The method relies on external induction and B-mode capture of cylindrical shear waves that satisfy the Bessel wave equation for efficient fit-based parameter recovery. B-THE was demonstrated in polyacrylamide phantoms in the frequency range of 20–200 Hz and was cross-validated by magnetic resonance elastography (MRE) using clinical 3-T MRI and compact 0.5-T tabletop MRI scanners. Frequency-independent material parameters were derived from rheological models and validated by numerical simulations.

B-THE quantified frequency-resolved SWS and PR 13 to 176 times faster than more expensive clinical MRE and tabletop MRE and have a good accuracy (relative deviation to reference: 6 %, 10 % and 4 % respectively). Simulations of liver-mimicking material phantoms showed that a simultaneous fit of SWS and PR based on the fractional Maxwell rheological model outperformed a fit on PR solely.

B-THE provides a comprehensive and fast elastography technique for the quantitative characterization of the viscoelastic behavior of soft tissue mimicking materials.

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基于贝塞尔函数的时间谐波超声弹性成像（B-THE）对粘弹性材料特性进行快速宽带表征

弹性成像是一种新兴的诊断技术，它使用超声波成像或磁共振成像等传统成像模式来量化组织硬度。然而，不同的弹性成像方法提供不同的硬度值，需要使用表征良好的模型或组织样本进行校准。因此，我们提出了基于贝塞尔拟合的超声时间谐波弹性成像（B-THE），作为一种新型工具，在广泛的谐波振动频率范围内快速反馈与刚度相关的剪切波速度（SWS）和与粘度相关的波穿透率（PR）。该方法依赖于外部感应和圆柱剪切波的 B 模式捕捉，这些剪切波满足贝塞尔波方程，可有效拟合参数恢复。B-THE 在聚丙烯酰胺模型中的频率范围为 20-200 Hz，并通过使用临床 3-T MRI 和紧凑型 0.5-T 桌面 MRI 扫描仪进行的磁共振弹性成像 (MRE) 进行了交叉验证。B-THE量化频率分辨的SWS和PR的速度比昂贵的临床MRE和台式MRE快13到176倍，而且准确度高（与参考值的相对偏差分别为6%、10%和4%）。模拟肝脏仿真材料模型的结果表明，基于分数麦克斯韦流变模型同时拟合 SWS 和 PR 的结果优于仅拟合 PR 的结果。B-THE 为定量表征软组织仿真材料的粘弹性行为提供了一种全面、快速的弹性成像技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.