{"title":"Changes in hematopoietic stem cell numbers following acute exercise in non-athlete marathon runners","authors":"Özgür Günaştı , Çiğdem Özdemir , Kerem T. Özgünen , Gizem Çiftdal , Ertuğrul Gezgin , Selcen Korkmaz Eryılmaz , Ömer Cumhur Boyraz , Abdullah Kılcı , Ümüt Adaş , Bülent Antmen , Sanlı Sadi Kurdak","doi":"10.1016/j.advms.2024.09.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Hematopoietic stem cell (HSC) transplant is one of the curative methods for some patients with hematological malignancies. Granulocyte colony-stimulating factor (G-CSF) is the most common drug used to mobilize CD34<sup>+</sup> cells, generally found in small numbers. Recent evidence showed that exercise causes transient mobilization in HSC. However, the type and intensity of exercise have not been fully revealed. We aimed to detect a significant increase in stem cell levels following 60 min of running at a personalized running pace.</p></div><div><h3>Materials/methods</h3><p>Eighteen runners, 48.2 ± 1.9 years with peak oxygen consumption of 46.2 ± 1.4 ml/kg/min, were enrolled in the study. The cardiopulmonary exercise test was performed to determine the individual running pace, and the participants ran 60-min on a treadmill at an intensity close to their ventilatory threshold (VT). The blood sampling for HSC count was performed before, immediately after, at the 1st, 4th and 24th hour after the 60-min running.</p></div><div><h3>Results</h3><p>The CD34<sup>+</sup> HSCs were 13.9 ± 2.3 cells/μl before and significantly increased immediately after to 19.5 ± 3.6 cells/μl (p < 0.05). The consecutive HSC counts were 15.3 ± 2.2, 19.5 ± 4.8 and 15.1 ± 3.4 cells/μl at the 1st, 4th, and 24th hour, respectively.</p></div><div><h3>Conclusion</h3><p>The individual data showed that some runners had higher HSC levels than the transplantation limit before and after the 60-min running trail, which was maintained for 24 h. Pre-running high CD34<sup>+</sup> HSCs may reflect an adaptive response to regular exercise, with a 60-min run near the VT further elevating HSCs. Individualized exercise may be a valuable tool to mobilize the CD34<sup>+</sup> HSCs in peripheral blood for donors.</p></div>","PeriodicalId":7347,"journal":{"name":"Advances in medical sciences","volume":"69 2","pages":"Pages 416-420"},"PeriodicalIF":2.5000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in medical sciences","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1896112624000518","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose
Hematopoietic stem cell (HSC) transplant is one of the curative methods for some patients with hematological malignancies. Granulocyte colony-stimulating factor (G-CSF) is the most common drug used to mobilize CD34+ cells, generally found in small numbers. Recent evidence showed that exercise causes transient mobilization in HSC. However, the type and intensity of exercise have not been fully revealed. We aimed to detect a significant increase in stem cell levels following 60 min of running at a personalized running pace.
Materials/methods
Eighteen runners, 48.2 ± 1.9 years with peak oxygen consumption of 46.2 ± 1.4 ml/kg/min, were enrolled in the study. The cardiopulmonary exercise test was performed to determine the individual running pace, and the participants ran 60-min on a treadmill at an intensity close to their ventilatory threshold (VT). The blood sampling for HSC count was performed before, immediately after, at the 1st, 4th and 24th hour after the 60-min running.
Results
The CD34+ HSCs were 13.9 ± 2.3 cells/μl before and significantly increased immediately after to 19.5 ± 3.6 cells/μl (p < 0.05). The consecutive HSC counts were 15.3 ± 2.2, 19.5 ± 4.8 and 15.1 ± 3.4 cells/μl at the 1st, 4th, and 24th hour, respectively.
Conclusion
The individual data showed that some runners had higher HSC levels than the transplantation limit before and after the 60-min running trail, which was maintained for 24 h. Pre-running high CD34+ HSCs may reflect an adaptive response to regular exercise, with a 60-min run near the VT further elevating HSCs. Individualized exercise may be a valuable tool to mobilize the CD34+ HSCs in peripheral blood for donors.
期刊介绍：
Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines.
The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments.
Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines.
The journal welcomes submissions from the following disciplines:
General and internal medicine,
Cancer research,
Genetics,
Endocrinology,
Gastroenterology,
Cardiology and Cardiovascular Medicine,
Immunology and Allergy,
Pathology and Forensic Medicine,
Cell and molecular Biology,
Haematology,
Biochemistry,
Clinical and Experimental Pathology.
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