TRP channels in cancer: Therapeutic opportunities and research strategies

IF 9.1 2区医学 Q1 PHARMACOLOGY & PHARMACY Pharmacological research Pub Date : 2024-09-19 DOI:10.1016/j.phrs.2024.107412

Jiahui Xu , Ziming Wang , Yuqing Niu , Yuping Tang , Yuwei Wang , Jumin Huang , Elaine Lai-Han Leung

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Abstract

The influence of gut microbiota on transient receptor potential (TRP) channels has been identified as an important element in the development of gastrointestinal conditions, yet its involvement in cancer progression is not as thoroughly understood. This review explores the multifaceted roles of TRP channels in oncogenesis and emphasizes their significance in cancer progression and therapeutic outcomes. Critical focus was placed on the influence of traditional medicines, such as traditional Chinese medicine (TCM) related aromatic medicines, on TRP channel functions. Moreover, we explored the interplay between the gut microbiota and TRP channels in cancer signaling, highlighting the therapeutic potential of targeting this axis in cancer treatment. The impact of current therapies on TRP channel function was examined, demonstrating the need for a comprehensive understanding of how different modalities affect TRP channels in cancer. Technological advancements, including artificial intelligence (AI) tools and computer-aided drug development (CADD), have been discussed in the context of leveraging TRP channels for innovative cancer therapies. Future directions emphasize the potential applications of TRP channel research in advancing cancer treatment and enhancing patients' well-being.

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癌症中的 TRP 通道：治疗机会与研究策略

肠道微生物群对瞬时受体电位（TRP）通道的影响已被确定为胃肠道疾病发展中的一个重要因素，但对其在癌症进展中的参与却了解得不那么透彻。本综述探讨了 TRP 通道在肿瘤发生中的多方面作用，并强调了它们在癌症进展和治疗结果中的重要意义。重点关注传统药物，如与中药相关的芳香类药物对 TRP 通道功能的影响。此外，我们还探讨了肠道微生物群与 TRP 通道在癌症信号转导中的相互作用，强调了在癌症治疗中针对这一轴心的治疗潜力。我们还研究了当前疗法对TRP通道功能的影响，表明有必要全面了解不同疗法如何影响癌症中的TRP通道。在利用 TRP 通道创新癌症疗法的背景下，还讨论了技术进步，包括人工智能（AI）工具和计算机辅助药物开发（CADD）。未来发展方向强调了 TRP 通道研究在推进癌症治疗和提高患者福祉方面的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacological research 医学-药学

CiteScore

18.70

自引率

3.20%

发文量

491

审稿时长

8 days

期刊介绍： Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Pharmacological research publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.