Zinc pathogenic importance in correcting immunity and restoring public health in the post-COVID period: An overview

IF 3.7 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-09-21 DOI:10.1016/j.cyto.2024.156761
Maria Sankova , Vladimir Nikolenko , Marine Oganesyan , Yurii Vinnik , Liliya Gavryushova , Sofya Redina , Negorya Rizaeva , Aleksey Sankov , Kirill Bulygin , Andzhela Vovkogon , André Pontes-Silva , Yury Zharikov
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Abstract

Context: The problem of correcting immune system function and compensating for co-morbidities becomes particularly clinically significant in the post-COVID period. There is evidence that certain trace elements in the human body, particularly zinc ions, play a critical role in restoring the function of the immune system and internal organs. Objective: To analyze the mechanisms of zinc action maintaining the body homeostasis in order to justify pathogenetically the inclusion of zinc drugs in the therapy of patients in the post-COVID period. Methods: Data from Elsevier, Global Health, PubMed-NCBI, Embase, MEDLINE, Scopus, Research gate, RSCI Scopus, Cochrane Library, Google Academy, e-LIBRARY.RU and CyberLeninka were used. Results: This review showed that the importance of zinc in maintaining body homeostasis in the post-COVID period is determined by its multifaceted effect on all parts of the immune system, its anti-inflammatory activity, antimicrobial properties and participation in the restoration of internal organ function. Elimination of zinc deficiency in the post-COVID period is essential to support immunity, compensate for comorbidities and reduce the risk of complications. The impossibility of synthesizing zinc in the body requires its constant intake in sufficient quantities. Zinc levels are significantly reduced after infectious diseases, as this element is specifically distributed to organs and tissues to maintain immunological and metabolic functions. The degree of zinc deficiency is associated with the severity of COVID-19 and the post-COVID period. It is pathogenetically justified to prescribe zinc drugs in the post-COVID period, the choice of which should take into account comorbidities and severity of hypozincemia. Conclusion: Regularly administered therapy with zinc drugs in the post-COVID period will help correct the population immunity and restore public health.

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锌致病剂在后 COVID 时期纠正免疫和恢复公众健康方面的重要性:概述
背景:在后 COVID 期,纠正免疫系统功能和补偿并发症的问题在临床上变得尤为重要。有证据表明,人体内的某些微量元素,尤其是锌离子,在恢复免疫系统和内脏器官功能方面发挥着至关重要的作用。研究目的分析锌在维持机体平衡方面的作用机制,以便从病理学角度证明将锌药物纳入后 COVID 期患者的治疗中是合理的。研究方法数据来源:Elsevier、Global Health、PubMed-NCBI、Embase、MEDLINE、Scopus、Research gate、RSCI Scopus、Cochrane Library、Google Academy、e-LIBRARY.RU 和 CyberLeninka。结果综述显示,锌对免疫系统各部分的多方面影响、抗炎活性、抗菌特性以及参与内脏器官功能的恢复,决定了锌在 COVID 后时期维持机体平衡的重要性。在后 COVID 期间消除锌缺乏症对于支持免疫力、补偿并发症和降低并发症风险至关重要。由于体内无法合成锌,因此需要不断摄入足量的锌。感染性疾病后,体内的锌含量会明显降低,因为这种元素专门分布在器官和组织中,以维持免疫和新陈代谢功能。缺锌的程度与 COVID-19 的严重程度和 COVID 后的时期有关。从病理学角度来看,在 COVID 后时期处方锌药物是合理的,但在选择药物时应考虑到合并症和低锌血症的严重程度。结论在禽流感后时期定期使用锌药物治疗将有助于纠正人群免疫力和恢复公众健康。
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来源期刊
Cytokine
Cytokine 医学-免疫学
CiteScore
7.60
自引率
2.60%
发文量
262
审稿时长
48 days
期刊介绍: The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.
期刊最新文献
TNF-α/IL-1β/IL-1α/IL-12 inflammatory cytokine axes coupled with TLR1/TLR3/TLR5/MYD88 immune signaling pathway over-activation contribute to simultaneous carotid and coronary artery and occlusion in elderly patients Antibody isotyping and cytokine profiling in natural cases of Burkholderia mallei infection (glanders) in equines The relationship between 25-hydroxyvitamin D and markers of intestinal and systemic inflammation in undernourished and non-undernourished children, 6–59 months Risk factors associated with short-term mortality in patients with candidemia and the predictive value of serum cytokine level The multifunctional role of IFN-γ in Galleria mellonella (Lepidoptera) immunocompetent cells
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