{"title":"On-demand release of CO in dual-responsive nanocomposite hydrogels for wound dressing","authors":"","doi":"10.1016/j.surfin.2024.105133","DOIUrl":null,"url":null,"abstract":"<div><p>Gaseous signaling molecules, especially carbon monoxide (CO), hold promising potential for disease management. The therapeutic efficacy of CO is closely tied to its concentration, however, maintaining it at optimal levels for both efficacy and safety is highly challenging. To address this, we designed a dual-responsive (pH/red light) nanocomposite hydrogel for on-demand CO release. We first synthesized a hybrid nanocomposite (CaCO<sub>3</sub>@AgCCN) comprising a CO<sub>2</sub> donor (CaCO<sub>3</sub>) and a photocatalyst (Ag<sub>3</sub>PO<sub>4</sub>-decorated carbon dot g-C<sub>3</sub>N<sub>4</sub>, AgCCN) capable of converting CO<sub>2</sub> to CO. The size of CaCO<sub>3</sub> particles was approximately 40 nm, while that of AgCCN was around 150 nm in this nanocomposite. CaCO<sub>3</sub>@AgCCN was then incorporated into chitosan (CS) to form a nanocomposite hydrogel. This nanocomposite hydrogel could respond to a mildly acidic environment due to bacterial growth, generating CO<sub>2</sub> exactly where it is needed (the wound site), which would be subsequently catalytically converted to CO by AgCCN under 630-nm red light illumination to facilitate wound healing. The generated CO, readily controlled by adjusting the CaCO<sub>3</sub>@AgCCN content in the nanocomposite hydrogel and the red-light illumination time (the CO concentration reaching 4.7 μM after 10-min illumination), has demonstrated strong bactericidal and anti-inflammatory effects, both essential in facilitating wound healing as shown in both in vitro and in vivo studies. Coupled with satisfactory biocompatibility, this dual-responsive nanocomposite hydrogel appears to hold great promise for safe and effective applications of CO in biomedical fields.</p></div>","PeriodicalId":22081,"journal":{"name":"Surfaces and Interfaces","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surfaces and Interfaces","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468023024012896","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Gaseous signaling molecules, especially carbon monoxide (CO), hold promising potential for disease management. The therapeutic efficacy of CO is closely tied to its concentration, however, maintaining it at optimal levels for both efficacy and safety is highly challenging. To address this, we designed a dual-responsive (pH/red light) nanocomposite hydrogel for on-demand CO release. We first synthesized a hybrid nanocomposite (CaCO3@AgCCN) comprising a CO2 donor (CaCO3) and a photocatalyst (Ag3PO4-decorated carbon dot g-C3N4, AgCCN) capable of converting CO2 to CO. The size of CaCO3 particles was approximately 40 nm, while that of AgCCN was around 150 nm in this nanocomposite. CaCO3@AgCCN was then incorporated into chitosan (CS) to form a nanocomposite hydrogel. This nanocomposite hydrogel could respond to a mildly acidic environment due to bacterial growth, generating CO2 exactly where it is needed (the wound site), which would be subsequently catalytically converted to CO by AgCCN under 630-nm red light illumination to facilitate wound healing. The generated CO, readily controlled by adjusting the CaCO3@AgCCN content in the nanocomposite hydrogel and the red-light illumination time (the CO concentration reaching 4.7 μM after 10-min illumination), has demonstrated strong bactericidal and anti-inflammatory effects, both essential in facilitating wound healing as shown in both in vitro and in vivo studies. Coupled with satisfactory biocompatibility, this dual-responsive nanocomposite hydrogel appears to hold great promise for safe and effective applications of CO in biomedical fields.
期刊介绍:
The aim of the journal is to provide a respectful outlet for ''sound science'' papers in all research areas on surfaces and interfaces. We define sound science papers as papers that describe new and well-executed research, but that do not necessarily provide brand new insights or are merely a description of research results.
Surfaces and Interfaces publishes research papers in all fields of surface science which may not always find the right home on first submission to our Elsevier sister journals (Applied Surface, Surface and Coatings Technology, Thin Solid Films)