A Dual Membrane Electrodialytic Phosphoric Acid Eluent Generator for Ion Exclusion Chromatography—A Gas-Free Electrodialytic Phosphoric Acid Generator

IF 2.8 3区工程技术 Q2 CHEMISTRY, ANALYTICAL Journal of separation science Pub Date : 2024-09-20 DOI:10.1002/jssc.202400536

Xiaolu Sun, Jingwen Tang, Weiqing Chen, Feifang Zhang, Bingcheng Yang

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Abstract

Relative to suppressed conductometric anion exchange chromatography, conductometric ion exclusion chromatography (IEC) is much less popular. Poor limit of detection and manual preparation of eluent are primarily responsible for this. We describe an electrodialytic phosphoric eluent generator for the online production of phosphoric acid eluent at a concentration exceeding 35 mM. It is a sandwiched configuration consisting of three channels isolated by stacked anion exchange membranes and a bipolar membrane plus stacked anion exchange membrane. Such a unique configuration ensures the production of gas-free eluent, obviating the need for a gas removal device. The resulting eluent concentration is controlled by varying the current. Coupled with an ultraviolet absorbance detector, a 0.04–16.67 mg/L limit of detection for model organic acids was achieved by IEC equipped with an electrodialytic phosphoric eluent generator.

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用于离子排阻色谱法的双膜电解磷酸流体发生器--无气电解磷酸发生器

与抑制电导阴离子交换色谱法相比，电导离子排阻色谱法（IEC）不太流行。检测限低和人工配制洗脱液是造成这一现象的主要原因。我们介绍了一种用于在线生产浓度超过 35 mM 的磷酸洗脱液的电拨磷洗脱液发生器。它是一种夹层结构，由叠层阴离子交换膜隔离的三个通道和双极膜加叠层阴离子交换膜组成。这种独特的配置可确保产生无气的洗脱液，从而无需使用除气装置。产生的洗脱液浓度可通过改变电流来控制。IEC 配有电拨磷洗脱液发生器，与紫外吸收检测器配合使用，可达到 0.04-16.67 mg/L 的有机酸模型检测限。

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来源期刊

Journal of separation science 化学-分析化学

CiteScore

6.30

自引率

16.10%

发文量

408

审稿时长

1.8 months

期刊介绍： The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.