Leptin, ghrelin and high-molecular-weight adiponectin in relation to anxiety in older adults

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Psychoneuroendocrinology Pub Date : 2024-09-19 DOI:10.1016/j.psyneuen.2024.107190

Merel van Andel , Natasja M. van Schoor , Nicole C. Korten , Annemieke C. Heijboer , Madeleine L. Drent

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Abstract

Background

Leptin and ghrelin have been linked to depressive symptoms in older adults. There is a large overlap between depression and anxiety in this group. It is unclear whether the same associations exist with anxiety. Adiponectin has an inverse association with anxiety in older adults. However, the association between the most biologically active isoform - high-molecular-weight (HMW) adiponectin - and anxiety has not been previously reported.

Methods

We analyzed the association between leptin, ghrelin and HMW adiponectin and general symptoms of anxiety (HADS-A score ≥ 7) at baseline and after three years of follow-up in a population based cohort of older adults in the Netherlands (n = 898) using multivariable logistic regression analyses.

Results

For leptin there was significant effect modification by sex. We found a positive association between leptin and general symptoms of anxiety in men at baseline and after three years of follow-up after adjusting for depressive symptoms, when comparing the third to the first leptin tertile (T3 vs T1 OR 3.40, 95 % CI 1.08 – 10.78).

We found no significant associations for ghrelin.

HMW adiponectin was associated with general symptoms of anxiety at follow up. We found a positive association both before and after adjustment for depressive symptoms (T3 vs T1 OR 3.26, 95 % CI 1.36 – 7.83).

Conclusions

Our results showed significant associations in men only between leptin and HMW adiponectin and general symptoms of anxiety after three years of follow up. Our findings contribute to further insight into the pathophysiology of anxiety in older adults. However, further research is necessary as we show associations.

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瘦素、胃泌素和高分子量脂肪连通素与老年人焦虑的关系

背景瘦素和胃泌素与老年人的抑郁症状有关。在这一群体中，抑郁症和焦虑症有很大的重叠。目前还不清楚焦虑是否也与抑郁有同样的联系。在老年人中，脂肪连接蛋白与焦虑呈反向关系。方法我们使用多变量逻辑回归分析方法，分析了荷兰老年人群（n = 898）中瘦素、胃泌素和高分子量脂肪连通素在基线时和随访三年后与一般焦虑症状（HADS-A 评分≥ 7 分）之间的关系。在将瘦素三等分与瘦素一等分（T3 vs T1 OR 3.40, 95 % CI 1.08 - 10.78）进行比较后，我们发现在基线和三年随访后，瘦素与男性的一般焦虑症状呈正相关（T3 vs T1 OR 3.40, 95 % CI 1.08 - 10.78）。我们发现，在对抑郁症状进行调整之前和调整之后（T3 vs T1 OR 3.26，95 % CI 1.36 - 7.83），两者之间均存在正相关。我们的研究结果有助于进一步了解老年人焦虑的病理生理学。不过，由于我们的研究显示了相关性，因此有必要开展进一步的研究。

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.