{"title":"Electrochemical selenocyclization of N-alkyl anilines: Access to 3-selenyl quinolines","authors":"Longqiang Zhao, Huimin Li, Mengyu Peng, Shoucai Wang, Mingzhe Li, Qingge Zhao, Wenxiu Huang, Guangbin Jiang, Fanghua Ji","doi":"10.1016/j.tet.2024.134257","DOIUrl":null,"url":null,"abstract":"<div><p>3-Selenyl quinolines are an important class of compounds that have found significant applications in pharmaceuticals and synthetic chemistry. Herein, we describe an electrochemical oxidative selenocyclization under undivided electrolytic conditions, thereby providing an efficient rout to access 3-selenyl quinolines. The merit of this method has been well demonstrated by its green and environmental-friendly conditions, being external oxidant-free, short reaction time, broad substrate scope and ease of scale-up to gram scale.</p></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"167 ","pages":"Article 134257"},"PeriodicalIF":2.1000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402024004381","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
3-Selenyl quinolines are an important class of compounds that have found significant applications in pharmaceuticals and synthetic chemistry. Herein, we describe an electrochemical oxidative selenocyclization under undivided electrolytic conditions, thereby providing an efficient rout to access 3-selenyl quinolines. The merit of this method has been well demonstrated by its green and environmental-friendly conditions, being external oxidant-free, short reaction time, broad substrate scope and ease of scale-up to gram scale.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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