gem-Difluoroallene (DFA): an emerging versatile synthetic precursor to enable diverse fluorinated molecules

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-09-11 DOI:10.1039/d4ob01253d
Kota Sathish , Swati Jain , Naveen Sihag , M. Ramu Yadav
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Abstract

Organofluorine compounds are increasingly found in diverse fields, such as pharmaceuticals, agrochemicals, and materials science. gem-Difluoroallenes, which have gem-difluoro alkenes and allenes-like properties, offer a distinct and adaptable platform for novel synthetic transformations. Their distinctiveness is highlighted by various strategies, where the gem-difluoro group's presence plays a pivotal role in successful reactions. This review article presents a comprehensive overview of the latest progress in utilizing gem-difluoroallenes for selective additions, defluorination, as well as cycloaddition and cyclization reactions. We also discuss the limitations and future directions in this area, inspiring further exploration and innovation.

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gem-二氟甲苯 (DFA):一种新兴的多功能合成前体,可生成多种氟化分子。
有机氟化合物越来越多地出现在医药、农用化学品和材料科学等不同领域。具有宝石-二氟烯烃和类烯特性的宝石-二氟烯烃为新型合成转化提供了一个独特且适应性强的平台。它们的独特性通过各种策略得以凸显,在这些策略中,宝石-二氟基团的存在在成功反应中起着关键作用。这篇综述文章全面概述了利用宝石二氟烯类进行选择性加成、脱氟以及环加成和环化反应的最新进展。我们还讨论了这一领域的局限性和未来发展方向,激励人们进一步探索和创新。
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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