gem-Difluoroallene (DFA): an emerging versatile synthetic precursor to enable diverse fluorinated molecules

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-09-18 DOI:10.1039/D4OB01253D
Kota Sathish, Swati Jain, Naveen Sihag and M. Ramu Yadav
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Abstract

Organofluorine compounds are increasingly found in diverse fields, such as pharmaceuticals, agrochemicals, and materials science. gem-Difluoroallenes, which have gem-difluoro alkenes and allenes-like properties, offer a distinct and adaptable platform for novel synthetic transformations. Their distinctiveness is highlighted by various strategies, where the gem-difluoro group's presence plays a pivotal role in successful reactions. This review article presents a comprehensive overview of the latest progress in utilizing gem-difluoroallenes for selective additions, defluorination, as well as cycloaddition and cyclization reactions. We also discuss the limitations and future directions in this area, inspiring further exploration and innovation.

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gem-二氟甲苯 (DFA):一种新兴的多功能合成前体,可生成多种氟化分子。
有机氟化合物越来越多地出现在医药、农用化学品和材料科学等不同领域。具有宝石-二氟烯烃和类烯特性的宝石-二氟烯烃为新型合成转化提供了一个独特且适应性强的平台。它们的独特性通过各种策略得以凸显,在这些策略中,宝石-二氟基团的存在在成功反应中起着关键作用。这篇综述文章全面概述了利用宝石二氟烯类进行选择性加成、脱氟以及环加成和环化反应的最新进展。我们还讨论了这一领域的局限性和未来发展方向,激励人们进一步探索和创新。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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