Recent advances in the multicomponent synthesis of pyrazoles.

Abstract

Pyrazole moiety is considered as an important N-heterocycle in pharmaceuticals and many other functional molecules. The utilization of multicomponent reaction is a major tool in the current approaches of pyrazole synthesis. Considering the power and significance of multicomponent pyrazole synthesis, we review herein the latest developments in this field. According to the typical features, the contents are divided into reactions with different NN fragment sources, such as hydrazine, hydrazone, amidine, nitrile, and diazo compounds, in the pyrazole ring construction, covering the works published since 2019 to date.