Valorization of grape pomace extracts against cranberry, elderberry, rose hip berry, goji berry and raisin extracts: Phytochemical profile and in vitro biological activity.

IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2025-01-15 Epub Date: 2024-09-18 DOI:10.1016/j.foodchem.2024.141323
Lorenza Marinaccio, Giulia Gentile, Eulogio J Llorent-Martínez, Gokhan Zengin, Domiziana Masci, Federica Flamminii, Azzurra Stefanucci, Adriano Mollica
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Abstract

The circular economy is gaining attention around the world as a sustainable approach to tackling environmental problems, promoting more responsible management of resources. The aim of this work is the valorization of grape pomace as a waste product of agrifood chain. We prepared decoction (DC), ultrasound-assisted and microwave-assisted extracts (UAE and MAE respectively) of grape pomace, determining their phytochemical profile (using HPLC-ESI-Q-TOF-MS), antioxidant activity and enzyme inhibitory effects. Then, the results were compared with those of raisins and several edible berries already present in the market. Grape pomace extracts presented the highest total phenolic content (62-68 mg gallic acid equivalents/g; mg GAE/g), whereas the concentrations in the other berries were 4-43 mg GAE/g. These results were in agreement with the higher antioxidant activity and tyrosinase inhibition observed in grape pomace compared with the other berries, except for the metal chelating activity. The main compounds in grape pomace extracts were flavonoids (particularly quercetin glycosides), followed by organic acids (citric, isocitric and gallic acids). These results open new perspectives in the development of food supplements and nutraceuticals based on grape pomace extracts.

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葡萄渣提取物与蔓越莓、接骨木果、玫瑰果、枸杞和葡萄干提取物的比对:植物化学成分概况和体外生物活性。
循环经济作为一种解决环境问题的可持续方法,正在受到全世界的关注,它促进了更负责任的资源管理。这项工作的目的是对作为农业食品链废弃物的葡萄渣进行增值。我们制备了葡萄渣的煎煮提取物(DC)、超声波辅助提取物(UAE)和微波辅助提取物(MAE),测定了它们的植物化学成分(采用 HPLC-ESI-Q-TOF-MS 法)、抗氧化活性和酶抑制作用。然后,将结果与葡萄干和市场上已有的几种食用浆果进行了比较。葡萄渣提取物的总酚含量最高(62-68 毫克没食子酸当量/克;毫克 GAE/克),而其他浆果的总酚含量为 4-43 毫克 GAE/克。除金属螯合活性外,这些结果与在葡萄渣中观察到的比其他浆果更高的抗氧化活性和酪氨酸酶抑制作用相一致。葡萄渣提取物中的主要化合物是黄酮类化合物(尤其是槲皮素苷),其次是有机酸(柠檬酸、异柠檬酸和没食子酸)。这些结果为开发基于葡萄渣提取物的食品补充剂和营养保健品开辟了新的前景。
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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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