{"title":"The Effects of Fisetin on Reducing Biological Aging: A Pilot Study.","authors":"Edwin Lee, Morgan Burns","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Fisetin, a natural flavonoid compound, is a senolytic agent that has shown promise in extending the lifespan of aging mice. Our goal was to determine whether Fisetin can reduce human biological aging, as verified by the TruAge test. This would be the first study in healthy human adults over the age of 50 years old to determine if Fisetin can reduce their biological age. Fisetin 500 mg daily was administered for one week per month for six months. The results showed that four out of ten healthy adults experienced a reduction in biological aging, five out of ten saw an increase, and one out of ten had no change. No adverse effects were noted among the ten subjects. Telomere lengths did not statistically change with the use of Fisetin. Because five of ten had an increase in biological age, taking Fisetin as an anti- aging agent is not recommended until more extensive studies are done.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alternative therapies in health and medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Fisetin, a natural flavonoid compound, is a senolytic agent that has shown promise in extending the lifespan of aging mice. Our goal was to determine whether Fisetin can reduce human biological aging, as verified by the TruAge test. This would be the first study in healthy human adults over the age of 50 years old to determine if Fisetin can reduce their biological age. Fisetin 500 mg daily was administered for one week per month for six months. The results showed that four out of ten healthy adults experienced a reduction in biological aging, five out of ten saw an increase, and one out of ten had no change. No adverse effects were noted among the ten subjects. Telomere lengths did not statistically change with the use of Fisetin. Because five of ten had an increase in biological age, taking Fisetin as an anti- aging agent is not recommended until more extensive studies are done.
期刊介绍：
Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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