Analysis of bone single-photon emission CT/CT and diffusion-weighted MR imaging in medication-related osteonecrosis of the jaw: focusing on the correlation between standardized uptake values and apparent diffusion coefficient values.

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING American journal of nuclear medicine and molecular imaging Pub Date : 2024-08-25 eCollection Date: 2024-01-01 DOI:10.62347/FFPG9819
Yasuhito Tezuka, Ichiro Ogura
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Abstract

The purpose of this study is to investigate bone SPECT/CT and diffusion-weighted MR imaging (DWI) in medication-related osteonecrosis of the jaw (MRONJ), focusing on the correlation between standardized uptake values (SUVs) and apparent diffusion coefficient (ADC) values. Twenty-nine patients with MRONJ who underwent SPECT/CT and DWI were included in this study. SUVs (maximum and mean) with SPECT/CT, and ADC values (maximum, mean and minimum) with DWI were analyzed on characteristics in MRONJ, such as stage, location, medication and underlying disease, by Mann-Whitney U test. Furthermore, the correlation between SUVs and ADC values for characteristics in MRONJ were assessed by Spearman's rank correlation test for nonparametric data. A p-value lower than 0.05 was considered as statistically significant. SUVs and ADC values have no significant differences for all characteristics in MRONJ. Negative correlations were found in all cases and in stage 2 cases, and no correlations were found in stage 3 cases. In addition, negative correlations were found in maxillary cases, mandibular cases, non-bisphosphonate cases, osteoporosis cases, and malignant tumor cases. In conclusion, this study found multiple correlations between SUVs and ADC values in MRONJ, especially in stage 2. Suggesting that ADC values and SUVs may change with disease progression and the possibility of predicting MRONJ progression by SUVs and ADC values.

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与药物相关的颌骨骨坏死的骨单光子发射 CT/CT 和弥散加权 MR 成像分析:重点关注标准化摄取值与表观弥散系数值之间的相关性。
本研究的目的是对药物相关性颌骨坏死(MRONJ)的骨SPECT/CT和弥散加权磁共振成像(DWI)进行研究,重点是标准化摄取值(SUV)和表观弥散系数(ADC)值之间的相关性。本研究纳入了 29 例接受 SPECT/CT 和 DWI 检查的 MRONJ 患者。通过 Mann-Whitney U 检验分析了 SPECT/CT 的 SUV 值(最大值和平均值)和 DWI 的 ADC 值(最大值、平均值和最小值)与 MRONJ 的分期、位置、药物治疗和基础疾病等特征的关系。此外,SUV 和 ADC 值与 MRONJ 特征之间的相关性还通过非参数数据的斯皮尔曼秩相关检验进行了评估。P 值小于 0.05 视为具有统计学意义。在 MRONJ 的所有特征中,SUV 和 ADC 值均无明显差异。所有病例和二期病例均呈负相关,三期病例无相关性。此外,在上颌骨病例、下颌骨病例、非双磷酸盐病例、骨质疏松症病例和恶性肿瘤病例中也发现了负相关。总之,本研究发现 SUV 与 ADC 值在 MRONJ 中存在多种相关性,尤其是在 2 期病例中。这表明 ADC 值和 SUV 值可能会随着疾病的进展而变化,并有可能通过 SUV 值和 ADC 值预测 MRONJ 的进展。
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来源期刊
American journal of nuclear medicine and molecular imaging
American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
4.00%
发文量
4
期刊介绍: The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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