Complete lasting reversal of polycystic ovary syndrome from intravenous umbilical cord derived mesenchymal stem cell infusion.

IF 1.5 Q4 CELL BIOLOGY American journal of stem cells Pub Date : 2024-08-25 eCollection Date: 2024-01-01 DOI:10.62347/TCZF4814
Chadwick Prodromos, Keanne Jabbarzadeh, Mark Hirmiz
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Abstract

Polycystic ovary syndrome (PCOS) presents distressing symptoms and stands as a primary cause of infertility. Currently, treatment options are limited to symptom management. This article presents a case study of a patient suffering from hair thinning associated with PCOS, treated with intravenous and subdermal injections of umbilical cord-derived mesenchymal stem cells (UC-MSCs). Remarkably, following treatment, the patient's 14-year history of menstrual irregularities and hormonal imbalances completely resolved, alongside the disappearance of ovarian cysts, with these improvements persisting for well over a year. Given PCOS's recognized inflammatory nature and the potent anti-inflammatory properties of UC-MSCs, we propose inflammation modulation as the likely mechanism of action. Further exploration is underway, actively seeking additional PCOS patients to ascertain whether similar therapeutic effects are reproducible or if this case represents an anomaly. This case underscores the potential of stem cell therapy as a revolutionary approach to PCOS management, addressing symptomatic relief and potentially underlying pathogenic mechanisms. The sustained clinical benefits observed advocate for comprehensive investigation into the efficacy and mechanisms of stem cell therapy in PCOS management.

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静脉输注脐带间充质干细胞可完全持久逆转多囊卵巢综合征。
多囊卵巢综合征(PCOS)会出现令人痛苦的症状,是导致不孕不育的主要原因之一。目前,治疗方法仅限于对症治疗。本文介绍了一个病例研究,患者因多囊卵巢综合征而头发稀疏,通过静脉注射和皮下注射脐带间充质干细胞(UC-MSCs)进行治疗。值得注意的是,治疗后,患者14年的月经不调和内分泌失调病史完全消失,卵巢囊肿也随之消失,这些改善持续了一年多。鉴于多囊卵巢综合症具有公认的炎症性质,而 UC 间充质干细胞具有强大的抗炎特性,我们认为炎症调节可能是其作用机制。我们正在进一步探索,积极寻找更多的多囊卵巢综合症患者,以确定类似的治疗效果是否具有可重复性,或者这个病例是否代表了一种异常现象。该病例强调了干细胞疗法作为治疗多囊卵巢综合症的革命性方法的潜力,既能缓解症状,又能解决潜在的致病机制。观察到的持续临床益处主张对干细胞疗法治疗多囊卵巢综合症的疗效和机制进行全面调查。
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Cellular therapies for idiopathic pulmonary fibrosis: current progress and future prospects. Complete lasting reversal of polycystic ovary syndrome from intravenous umbilical cord derived mesenchymal stem cell infusion. Examining the level of inflammatory cytokines TNF-α and IL-8 produced by osteoblasts differentiated from dental pulp stem cells. Exploring the application of stem cell technology in treating sensorineural hearing loss. Acoustic vibration promotes in vitro expansion of human embryonic stem cells.
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