Prognostic Value of Easy Albumin-Bilirubin Score for Radical Surgery in Patients With Gallbladder Carcinoma.

IF 1 4区医学 Q3 SURGERY American Surgeon Pub Date : 2025-02-01 Epub Date: 2024-09-15 DOI:10.1177/00031348241285188

Ming Xu, Chuanmin Deng, Yanfang Zhang, Zhongran Man, Song Yang, Song Xu

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Abstract

Background: To investigate the clinical significance of the easy albumin-bilirubin (EZ-ALBI) score as a prognostic indicator in postoperative patients with gallbladder carcinoma (GBC).

Methods: The comprehensive clinical and pathological records of 140 patients with GBC who underwent radical resection between January 2015 and December 2020 were retrospectively examined. Based on the EZ-ALBI score, the 140 GBC patients were categorized into two groups: a low EZ-ALBI score group (score ≤ -34.4) consisting of 108 patients and a high EZ-ALBI score group (score > -34.4) consisting of 32 patients. The association between the EZ-ALBI score and clinicopathological factors was assessed. Survival analysis was performed using the Kaplan-Meier method, and the Cox proportional hazard model was utilized to evaluate the impact of clinicopathological factors on prognosis.

Results: Significant differences were observed between the low EZ-ALBI score group and the high EZ-ALBI score group in terms of serum total bilirubin, serum albumin, CA19-9 levels, liver metastasis, and tumor TNM stage. The 5-year survival rate was significantly lower in the high EZ-ALBI score group compared to the low EZ-ALBI score group. Univariate analysis indicated that serum total bilirubin, lymph node metastasis, TNM stage, and EZ-ALBI score were closely related to overall survival (OS). Multivariate analysis identified TNM stage and EZ-ALBI score as independent prognostic factors for OS.

Conclusions: The EZ-ALBI score is a significant independent prognostic factor for overall survival in GBC patient's post-radical resection, highlighting its potential utility in clinical prognosis and patient management.

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胆囊癌患者接受根治性手术时白蛋白-胆红素简易评分的预后价值

背景：方法：回顾性研究2015年1月至2020年12月期间接受根治性切除术的140例GBC患者的临床和病理综合记录：方法：回顾性研究2015年1月至2020年12月期间接受根治性切除术的140例GBC患者的综合临床和病理记录。根据EZ-ALBI评分，将140例GBC患者分为两组：EZ-ALBI低分组（评分≤-34.4）108例，EZ-ALBI高分组（评分>-34.4）32例。评估了 EZ-ALBI 评分与临床病理因素之间的关联。采用Kaplan-Meier方法进行生存分析，并利用Cox比例危险模型评估临床病理因素对预后的影响：在血清总胆红素、血清白蛋白、CA19-9水平、肝转移和肿瘤TNM分期方面，低EZ-ALBI评分组与高EZ-ALBI评分组之间存在显著差异。与低EZ-ALBI评分组相比，高EZ-ALBI评分组的5年生存率明显较低。单变量分析表明，血清总胆红素、淋巴结转移、TNM分期和EZ-ALBI评分与总生存率（OS）密切相关。多变量分析确定TNM分期和EZ-ALBI评分是OS的独立预后因素：结论：EZ-ALBI评分是影响根治性切除术后GBC患者总生存期的一个重要独立预后因素，突出了其在临床预后和患者管理中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Surgeon 医学-外科

CiteScore

1.40

自引率

0.00%

发文量

623

期刊介绍： The American Surgeon is a monthly peer-reviewed publication published by the Southeastern Surgical Congress. Its area of concentration is clinical general surgery, as defined by the content areas of the American Board of Surgery: alimentary tract (including bariatric surgery), abdomen and its contents, breast, skin and soft tissue, endocrine system, solid organ transplantation, pediatric surgery, surgical critical care, surgical oncology (including head and neck surgery), trauma and emergency surgery, and vascular surgery.