Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla_NDM-5 and bla_KPC-3 from foreign fighters evacuated from Ukraine.

IF 4.1 2区医学 Q2 MICROBIOLOGY Antimicrobial Agents and Chemotherapy Pub Date : 2024-11-06 Epub Date: 2024-09-20 DOI:10.1128/aac.01090-24

Melissa J Martin, Ting L Luo, Valentyn Kovalchuk, Viacheslav Kondratiuk, Henry D Dao, Iryna Kovalenko, Brandon J Plaza, Joanna M Kettlewell, Cole P Anderson, Jason R Smedberg, Ana C Ong, Yoon I Kwak, Joshua S Hawley-Molloy, Jason W Bennett, Patrick T McGann, Francois Lebreton

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Abstract

Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla_NDM-5, bla_KPC-3, bla_CTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla_CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.

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检测从乌克兰撤出的外国战斗人员中携带 blaNDM-5 和 blaKPC-3 的流行性大肠埃希菌 ST-361 对头孢羟氨苄和阿曲南类/阿维菌素的耐药性。

基因组监测从一名乌克兰患者和四名撤往德国的外国伤兵身上检测到携带 blaNDM-5、blaKPC-3、blaCTX-M-15 和 rmtB1 的克隆大肠埃希菌序列 361 型分离株。由于存在 PBP3 YRIN 插入和 blaCMY-145 AmpC β-内酰胺酶，该菌株对碳青霉烯类、氨基糖苷类、头孢克肟和阿曲南/阿维菌素无敏感性。随着国际志愿者从乌克兰医疗后送回国，必须在民用、军用和退伍军人医疗保健系统之间协调开展监测工作，以防止进一步传播。

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.