Changes in the epidemiology of pediatric brain abscesses pre- and post-COVID-19 pandemic: a single-center study.

IF 2 3区医学 Q2 PEDIATRICS BMC Pediatrics Pub Date : 2024-09-21 DOI:10.1186/s12887-024-05082-6

Yuchen Liu, Zhenjiang Bai, Tianquan Yang, Bin Yuan, Yong Han, Yongjun Xiang, Ruxuan Zhou, Jingxuan Sun, Min Chen, Chuangli Hao, Hangzhou Wang

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Abstract

Background: An increased incidence of brain abscesses was observed post-COVID-19 pandemic. However, it remains unclear how the COVID-19 pandemic influenced the epidemiology of brain abscesses. This study aimed to investigate changes in the epidemiology of brain abscesses pre- and post-COVID-19 pandemic.

Methods: A retrospective study of demographic, clinical, radiological, and laboratory characteristics of patients with brain abscesses in Children's Hospital of Soochow University from 2015-2023 was performed.

Results: A total of 34 patients were admitted to the hospital during the study. The post-COVID-19 cohort had an average of 5.5 cases/year, which is a 129.2% increase compared to the pre-COVID-19 cohort's average of 2.4 cases/year. Additionally, the rates of fever upon admission (86.36% vs 50%, p = 0.04) and experiencing high-grade fever within 6 weeks before admission (40.91% vs 8.33%, p = 0.044) were significantly increased. A potential rise in the rate of intensive care unit admission was observed (36.36% vs 8.33%, p = 0.113). The average value of globulin in the post-COVID cohort was significantly higher compared to the pre-COVID cohort (31.60 ± 5.97 vs 25.50 ± 5.08, p = 0.009). Streptococcal infections were the predominant cause of brain abscesses in both cohorts (40% vs 43.75%, p = 0.57).

Conclusions: There was a significant increase in the number of brain abscess patients after the COVID-19 pandemic. This underscores the importance of children receiving the streptococcal vaccine.

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COVID-19大流行前后小儿脑脓肿流行病学的变化：一项单中心研究。

背景：COVID-19 大流行后，脑脓肿的发病率有所上升。然而，COVID-19 大流行对脑脓肿流行病学有何影响仍不清楚。本研究旨在调查 COVID-19 大流行前后脑脓肿流行病学的变化：方法：对2015-2023年苏州大学附属儿童医院脑脓肿患者的人口学、临床、放射学和实验室特征进行回顾性研究：研究期间共有34名患者入院治疗。与COVID-19前的平均每年2.4例相比，COVID-19后的患者平均每年5.5例，增加了129.2%。此外，入院时发热（86.36% vs 50%，p = 0.04）和入院前 6 周内发高烧（40.91% vs 8.33%，p = 0.044）的比例也显著增加。入住重症监护室的比例也有可能上升（36.36% vs 8.33%，p = 0.113）。COVID后组群的球蛋白平均值明显高于COVID前组群（31.60 ± 5.97 vs 25.50 ± 5.08，p = 0.009）。在两个队列中，链球菌感染是脑脓肿的主要病因（40% vs 43.75%，p = 0.57）：结论：COVID-19 大流行后，脑脓肿患者人数明显增加。结论：COVID-19 大流行后，脑脓肿患者人数明显增加，这突出表明了儿童接种链球菌疫苗的重要性。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.