The effectiveness of phytosomal curcumin on clinical and laboratory parameters of patients with multiple trauma admitted to the intensive care unit: a double-blind randomized placebo-controlled trial.

IF 3.3 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE BMC Complementary Medicine and Therapies Pub Date : 2024-09-17 DOI:10.1186/s12906-024-04639-3
Mahdiye Mirjalili, Amirhossein Sahebkar, Shirin Hassanizadeh, Zahra Kiani, Davood Soleimani, Sepide Amini, Babak Alikiaii, Seyed Adel Moallem, Gholamreza Askari, Saeed Abbasi, Mohammad Bagherniya
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Abstract

Background: Multiple trauma has serious complications, which increases the risk of morbidity and mortality in the patients. This study aimed to evaluate the impact of supplementation with phytosomal curcumin on clinical and laboratory factors in critically ill patients with multiple trauma.

Methods: In this double-blind trial, 53 patients with multiple trauma, who were admitted to the intensive care unit (ICU) were randomized to receive either 2 capsules, each capsule containing 250 mg phytosomal (a total of 500 mg daily) as an intervention group or 2 identical capsules (placebo capsules), each containing 250 mg maltodextrin for 7 days. Clinical and laboratory were parameters assessed before and after the intervention.

Results: After seven days of intervention, the mean increase from baseline in the Glasgow coma scale (GCS) score was significantly higher in the curcumin compared with the placebo group (P-value: 0.028), while the reduction in the APACHE-II score in the curcumin group was greater than that the placebo group in a marginally non-significant fashion (P-value: 0.055). Serum total bilirubin (P-value: 0.036) and quantitative C-reactive protein (CRP) (P-value: 0.044) levels significantly decreased while potassium (P-value: 0.01) significantly increased in the curcumin compared with the placebo group. Moreover, supplementation with phytosomal curcumin significantly increased platelet count (P-value: 0.024) as compared with placebo. The 28-day mortality rate was 7.7% (n: 2 patients) and 3.7% (n: 1 patients) in the placebo and curcumin groups, respectively (P-value > 0.05).

Conclusion: Phytosomal curcumin had beneficial effects on several clinical and laboratory factors including GCS, APACHEII, serum total bilirubin, CRP, and platelet count in ICU-admitted patients with multiple trauma.

Trial registration: IRCT20090306001747N1, Available on: https://www.irct.ir/trial/52692 . The first registration date was 12/01/2021.

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植物姜黄素对重症监护室多重创伤患者临床和实验室指标的影响:双盲随机安慰剂对照试验。
背景:多发性创伤具有严重的并发症,增加了患者发病和死亡的风险。本研究旨在评估补充植物姜黄素对多重创伤重症患者临床和实验室因素的影响:在这项双盲试验中,53 名入住重症监护室(ICU)的多发性创伤患者被随机分为干预组和安慰剂组,干预组接受 2 粒胶囊,每粒含有 250 毫克植物姜黄素(每天共 500 毫克),安慰剂组接受 2 粒相同的胶囊,每粒含有 250 毫克麦芽糊精,连续服用 7 天。干预前后对临床和实验室参数进行了评估:干预七天后,姜黄素组的格拉斯哥昏迷量表(GCS)评分与安慰剂组相比,从基线上升的平均值显著高于安慰剂组(P 值:0.028),而姜黄素组的 APACHE-II 评分下降幅度略高于安慰剂组(P 值:0.055)。与安慰剂组相比,姜黄素组的血清总胆红素(P 值:0.036)和定量 C 反应蛋白(CRP)(P 值:0.044)水平明显下降,而钾含量(P 值:0.01)则明显上升。此外,与安慰剂相比,补充植物姜黄素能明显增加血小板计数(P 值:0.024)。安慰剂组和姜黄素组的28天死亡率分别为7.7%(2例患者)和3.7%(1例患者)(P值>0.05):植物姜黄素对ICU收治的多发性创伤患者的GCS、APACHEII、血清总胆红素、CRP和血小板计数等多项临床和实验室指标均有益处:IRCT20090306001747N1, Available on: https://www.irct.ir/trial/52692 .首次注册日期为 2021 年 1 月 12 日。
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来源期刊
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
6.10
自引率
2.60%
发文量
300
审稿时长
19 weeks
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