Incidence of Infective Endocarditis Post-TPVR with MELODY Valve in Pediatric Patients: A Systematic Review and Meta-Analysis.

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reviews Pub Date : 2024-09-16 DOI:10.2174/011573403X324878240903045701
Sruthi Veldurthy, Deepali Shrivastava, Farhat Majeed, Tooba Ayaz, Aqssa Munir, Ali Haider, Maneeth Mylavarapu
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Abstract

Introduction: Infective Endocarditis (IE) has emerged to be one of the most impactful adverse complications post-transcatheter procedures, especially Transcatheter Pulmonary Valve Replacement (TPVR). We conducted a systematic review and meta-analysis with the aim of identifying the incidence of IE post-TPVR with the MELODY valve in the pediatric population.

Methods: A comprehensive literature search was performed across several prominent databases, including PubMed/MEDLINE, SCOPUS, and Science Direct. Studies compared the clinical outcomes of pediatric patients who received TPVR using the MELODY valve. Data extraction was done for variables like the total pediatric patient population that underwent TPVR with MELODY valve, mean age, the sex of the patients, the incidence rate of IE following the procedure, and the duration between the procedure and the occurrence of IE. Inverse Variance was used to estimate the incidence of IE in patients who underwent TPVR with respective 95% confidence interval (CI).

Results: In total, 4 studies with 414 pediatric patients who underwent TPVR using the MELODY valve were included in the study. The mean age of the study population was 12.7 ± 3.11 years. The pooled incidence of IE following TPVR with MELODY valve in the pediatric population was 17.70% (95% Cl 3.84-31.55; p<0.00001). Additionally, the mean length of duration to develop IE following TPVR with MELODY valve in the pediatric population was 2.18 years (95% Cl 0.35-4.01; p<0.00001).

Conclusion: Our meta-analysis reveals that IE post-TPVR with MELODY valve in pediatric patients is a significant complication, clinically and statistically. Further research needs to be done to understand the risk factors and develop better management strategies.

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儿科患者使用 MELODY 瓣膜进行 TPVR 术后感染性心内膜炎的发生率:系统性回顾和元分析。
导言:感染性心内膜炎(IE)已成为经导管手术,尤其是经导管肺动脉瓣置换术(TPVR)后影响最大的不良并发症之一。我们进行了一项系统性回顾和荟萃分析,旨在确定使用 MELODY 瓣膜进行经导管肺动脉瓣置换术后 IE 在儿科人群中的发病率:我们在多个知名数据库(包括 PubMed/MEDLINE、SCOPUS 和 Science Direct)中进行了全面的文献检索。研究比较了使用 MELODY 瓣膜进行 TPVR 的儿科患者的临床疗效。对使用 MELODY 瓣膜进行 TPVR 的儿科患者总人数、平均年龄、患者性别、术后 IE 发生率以及术后至发生 IE 的持续时间等变量进行了数据提取。研究采用反方差法估算了接受TPVR患者的IE发生率及相应的95%置信区间(CI):共有4项研究纳入了414名使用MELODY瓣膜进行TPVR的儿科患者。研究对象的平均年龄为(12.7 ± 3.11)岁。在儿科人群中,使用 MELODY 瓣膜进行 TPVR 后 IE 的总发生率为 17.70% (95% Cl 3.84-31.55; pConclusion):我们的荟萃分析表明,无论从临床角度还是从统计学角度来看,儿科患者使用 MELODY 瓣膜进行 TPVR 术后 IE 都是一种重要的并发症。需要进一步开展研究,以了解风险因素并制定更好的管理策略。
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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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