Distribution of esophageal inflammation in patients with eosinophilic esophagitis and its impact on diagnosis and outcome.

IF 4 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Digestive and Liver Disease Pub Date : 2024-09-13 DOI:10.1016/j.dld.2024.08.049
Andrea Sorge, Giovanni Aldinio, Beatrice Marinoni, Pierfancesco Visaggi, Roberto Penagini, Daria Maniero, Matteo Ghisa, Elisa Marabotto, Nicola de Bortoli, Andrea Pasta, Valentina Dipace, Francesco Calabrese, Maurizio Vecchi, Edoardo Vincenzo Savarino, Marina Coletta
{"title":"Distribution of esophageal inflammation in patients with eosinophilic esophagitis and its impact on diagnosis and outcome.","authors":"Andrea Sorge, Giovanni Aldinio, Beatrice Marinoni, Pierfancesco Visaggi, Roberto Penagini, Daria Maniero, Matteo Ghisa, Elisa Marabotto, Nicola de Bortoli, Andrea Pasta, Valentina Dipace, Francesco Calabrese, Maurizio Vecchi, Edoardo Vincenzo Savarino, Marina Coletta","doi":"10.1016/j.dld.2024.08.049","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the distribution of esophageal inflammation in patients with eosinophilic esophagitis (EoE) and its impact on diagnosis and outcome.</p><p><strong>Aims and methods: </strong>Data from consecutive adult EoE patients who were followed-up at four Italian referral centers from October 2022 to October 2023 were retrospectively collected.</p><p><strong>Results: </strong>One hundred forty-nine patients were included. Proximal EoE was observed in 8.1 % of patients; distal EoE in 27.5 %; and diffuse EoE in 64.4 %. Allergic rhinitis was more prevalent in distal and diffuse than proximal EoE (72.5 % vs. 61.5 % vs 33.3 %; P = 0.049). The prevalence of asthma, atopic dermatitis, oral allergy syndrome, and gastroesophageal reflux disease was not significantly different among the three EoE extent groups. Endoscopic inflammatory features at diagnosis were more prevalent in proximal EoE (91.7 % vs. 53.8 % distal [P = 0.01] vs. 66 % diffuse[P = 0.05]). No significant differences in fibrotic features and esophageal stenoses were observed. The clinical and histological remission rates after first-line therapy were comparable in all groups.</p><p><strong>Conclusion: </strong>Esophageal inflammation in EoE more frequently involves the entire esophagus, followed by isolated distal and proximal involvement. No clear correlation was observed between the histological extent of EoE at diagnosis and comorbidities or treatment response.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive and Liver Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.dld.2024.08.049","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: This study aimed to assess the distribution of esophageal inflammation in patients with eosinophilic esophagitis (EoE) and its impact on diagnosis and outcome.

Aims and methods: Data from consecutive adult EoE patients who were followed-up at four Italian referral centers from October 2022 to October 2023 were retrospectively collected.

Results: One hundred forty-nine patients were included. Proximal EoE was observed in 8.1 % of patients; distal EoE in 27.5 %; and diffuse EoE in 64.4 %. Allergic rhinitis was more prevalent in distal and diffuse than proximal EoE (72.5 % vs. 61.5 % vs 33.3 %; P = 0.049). The prevalence of asthma, atopic dermatitis, oral allergy syndrome, and gastroesophageal reflux disease was not significantly different among the three EoE extent groups. Endoscopic inflammatory features at diagnosis were more prevalent in proximal EoE (91.7 % vs. 53.8 % distal [P = 0.01] vs. 66 % diffuse[P = 0.05]). No significant differences in fibrotic features and esophageal stenoses were observed. The clinical and histological remission rates after first-line therapy were comparable in all groups.

Conclusion: Esophageal inflammation in EoE more frequently involves the entire esophagus, followed by isolated distal and proximal involvement. No clear correlation was observed between the histological extent of EoE at diagnosis and comorbidities or treatment response.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
嗜酸性粒细胞食管炎患者食管炎症的分布及其对诊断和预后的影响。
背景:本研究旨在评估嗜酸性粒细胞食管炎(EoE)患者食管炎症的分布及其对诊断和预后的影响:本研究旨在评估嗜酸性粒细胞食管炎(EoE)患者食管炎症的分布及其对诊断和预后的影响:回顾性收集了2022年10月至2023年10月期间在意大利四个转诊中心接受随访的连续成人食管炎患者的数据:结果:共纳入149名患者。8.1%的患者为近端性中耳炎,27.5%为远端性中耳炎,64.4%为弥漫性中耳炎。过敏性鼻炎在远端和弥漫性咽喉炎中的发病率高于近端咽喉炎(72.5% vs. 61.5% vs. 33.3%;P = 0.049)。哮喘、特应性皮炎、口腔过敏综合征和胃食管反流病的患病率在三组呃逆程度组间无明显差异。诊断时的内镜炎症特征在近端咽喉炎中更为普遍(91.7% 对 53.8% 远端[P = 0.01] 对 66% 弥漫性[P = 0.05])。在纤维化特征和食管狭窄方面没有观察到明显差异。各组患者在接受一线治疗后的临床和组织学缓解率相当:结论:食管炎患者的食管炎症多累及整个食管,其次是孤立的远端和近端受累。诊断时食管水肿的组织学范围与合并症或治疗反应之间没有明显的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Digestive and Liver Disease
Digestive and Liver Disease 医学-胃肠肝病学
CiteScore
6.10
自引率
2.20%
发文量
632
审稿时长
19 days
期刊介绍: Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.
期刊最新文献
Recent trends in foreign body ingestion (FBI) epidemiology: A national cohort study. Duodenal gastric heterotopia diagnosed by spectral CT. Feasibility, safety and efficacy of endoscopic submucosal dissection for recurrent superficial rectal neoplastic lesions after transanal microsurgery. Liver transplant for hepatocellular carcinoma in metabolic dysfunction-associated steatotic liver disease versus other etiologies: A meta-analysis. Sarcopenia in patients receiving TIPS is independently associated with increased risk of complications and mortality.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1