Novel technique utilizing polymethylmethacrylate cement for the treatment of pulsatile tinnitus caused by different sigmoid sinus pathologies.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-21 DOI:10.1007/s00405-024-08974-6
Homood M Almutairi, Khalid M Alkhalifah, Hareth Nasir Alhujaili, Saleh AlAmry
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Abstract

Purpose: Sigmoid sinus anomalies such as dehiscence or diverticula may present with pulsatile tinnitus (PT) and low-frequency hearing loss. Occasionally, these symptoms are severe, necessitating resurfacing of the affected area to restore a normal-appearing sinus wall. This study describes three cases wherein we managed PT attributed to sigmoid sinus anomalies using polymethylmethacrylate (PMMA) bone cement, a novel material.

Methods: Three patients with PT without any history of illnesses initially underwent cortical mastoidectomy to expose the affected area and resurface the sinus wall. Subsequently, PMMA bone cement was used to reconstruct any bony defects causing PT symptoms. Viscosity of the bone cement was altered based on specific characteristics and causes of the affected area. Additionally, we performed the water occlusion test (WOT), audiological assessment, the Tinnitus Handicap Inventory score (THI), and temporal computed tomography, both pre- and postoperatively, to assess the extent of PT.

Results: Preoperatively, all three patients had tinnitus that dissipated with pressure on the neck and the water occlusion test (WOT), with no reported vertigo, trauma, or ear infections. Moreover, all three cases had a severe handicap according to the THI. In contrast, all cases had reduced PT and a significantly decreased THI score postoperatively, as well as no recurrence or complications and no instances of increased intracranial hypertension at the 12-month follow-up.

Conclusion: All cases showed promising results, emphasizing the sustained benefits of this novel intervention for the management of PT.

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利用聚甲基丙烯酸甲酯粘合剂治疗不同乙状窦病变引起的搏动性耳鸣的新技术。
目的:乙状结肠窦异常(如开裂或憩室)可能会出现搏动性耳鸣(PT)和低频听力损失。有时,这些症状会很严重,需要对患处进行复位,以恢复正常的窦壁外观。本研究描述了三例使用新型材料聚甲基丙烯酸甲酯(PMMA)骨水泥治疗乙状窦异常引起的耳鸣的病例:三名无任何病史的 PT 患者最初接受了乳突皮质切除术,以暴露受影响区域并重塑窦壁。随后,使用 PMMA 骨水泥重建导致 PT 症状的骨缺损。骨水泥的粘度根据患处的具体特征和原因而改变。此外,我们还在术前和术后进行了闭水试验(WOT)、听力评估、耳鸣障碍量表评分(THI)和颞部计算机断层扫描,以评估 PT 的程度:结果:三位患者术前均有耳鸣,但在颈部加压和水闭塞试验(WOT)后耳鸣消失,无眩晕、外伤或耳部感染报告。此外,这三个病例都有严重的THI障碍。相比之下,所有病例术后 PT 均有所下降,THI 评分显著降低,并且在 12 个月的随访中没有出现复发或并发症,也没有出现颅内高压加重的情况:结论:所有病例均显示出良好的效果,强调了这种新型干预方法在治疗 PT 方面的持续优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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