Differentially methylated regions interrogated for metastable epialleles associate with offspring adiposity.

IF 3 4区医学 Q2 GENETICS & HEREDITY Epigenomics Pub Date : 2024-01-01 Epub Date: 2024-09-12 DOI:10.1080/17501911.2024.2359365

Stephanie W Waldrop, Katherine A Sauder, Sierra S Niemiec, Katerina J Kechris, Ivana V Yang, Anne P Starling, Wei Perng, Dana Dabelea, Sarah J Borengasser

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Abstract

Aim: Assess if cord blood differentially methylated regions (DMRs) representing human metastable epialleles (MEs) associate with offspring adiposity in 588 maternal-infant dyads from the Colorado Health Start Study.Materials & methods: DNA methylation was assessed via the Illumina 450K array (~439,500 CpG sites). Offspring adiposity was obtained via air displacement plethysmography. Linear regression modeled the association of DMRs potentially representing MEs with adiposity.Results & conclusion: We identified two potential MEs, ZFP57, which associated with infant adiposity change and B4GALNT4, which associated with infancy and childhood adiposity change. Nine DMRs annotating to genes that annotated to MEs associated with change in offspring adiposity (false discovery rate <0.05). Methylation of approximately 80% of DMRs identified associated with decreased change in adiposity.

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可转移外显子的不同甲基化区域与后代肥胖有关。

目的：评估科罗拉多州健康起步研究（Colorado Health Start Study）的 588 个母婴组合中，代表人类可转移外显子（MEs）的脐带血差异甲基化区域（DMRs）是否与后代肥胖有关：DNA 甲基化通过 Illumina 450K 阵列（约 439,500 个 CpG 位点）进行评估。后代的脂肪含量通过空气位移量血压计获得。线性回归模拟了可能代表ME的DMRs与脂肪率的关联：我们发现了两个潜在的MEs：ZFP57（与婴儿期脂肪变化有关）和B4GALNT4（与婴幼儿期脂肪变化有关）。注释到与后代脂肪变化相关的ME的基因的9个DMRs（假发现率

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.