{"title":"Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights.","authors":"Anisha Bhardwaj, Amit Dubey, Aisha Tufail, Nasir Tufail, Manish Kumar, Sapana Garg","doi":"10.1080/17568919.2024.2401310","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.<b>Materials & methods:</b> Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using <i>in vitro</i> assays and molecular docking studies.<b>Results:</b> The complexes exhibited significant antimalarial activity against <i>Plasmodium falciparum</i>, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17568919.2024.2401310","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies.Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.
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