More efficient endoscopic submucosal dissection with deep endotracheal intubation for superficial cervical esophageal carcinoma: a dual-center, prospective, randomized controlled study

IF 6.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gastrointestinal endoscopy Pub Date : 2025-03-01 DOI:10.1016/j.gie.2024.09.018

Yanqin Xu MD , Yinxin Wu MD , Wanyin Deng MD , Xianbin Guo MD , Pingting Gao MD , Shijie Yang MD , Yahua Chen MD , Pinghong Zhou MD , Wei Liang MD

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Abstract

Background and Aims

Deep endotracheal intubation (DET) has been proposed to improve cervical esophageal endoscopic submucosal dissection (ESD) because of the limited space and visibility. We aimed to evaluate the efficacy and safety of DET.

Methods

In the current dual-center trial, patients were randomized into DET or conventional endotracheal intubation (CET) groups. Complete resection rate, operation time, and adverse events were measured and compared.

Results

Fifty-nine patients (60 lesions) were assigned to the groups, showing comparable baseline characteristics. The complete resection rates were similarly high in both groups. However, DET significantly reduced ESD operation time (52.2 minutes vs 71.1 minutes, P < .001) and postoperative pain scores (3.1 vs 4.7, P < .01). Severe stenosis occurred more frequently in the CET patients (20% vs 0%, P = .035). No significant differences were observed in other adverse events.

Conclusions

DET can overcome technical challenges to improve therapeutic efficiency and safety. (Clinical trial registration number: NCT06420258.)

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更有效的内镜黏膜下剥离术与更深的气管插管治疗浅表颈段食管癌：一项双中心、前瞻性、随机对照研究。

背景和目的：由于空间和能见度有限，有人提出采用更深的气管内插管（DET）来改善颈部食管内镜黏膜下剥离术（CE-ESD）。我们旨在评估 DET 的有效性和安全性：在当前的双中心试验中，患者被随机分为深度组和传统气管插管组（CET）。结果：59 名患者（60 个病灶）被随机分为深部气管插管组和常规气管插管组：59名患者（60个病灶）被分配到两组，基线特征相当。两组的完全切除率相似。然而，DET大大缩短了ESD手术时间（52.2分钟 vs. 71.1分钟，p结论：DET可以克服技术难题，改善手术效果：DET 可以克服技术难题，提高治疗效率和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastrointestinal endoscopy 医学-胃肠肝病学

CiteScore

10.30

自引率

7.80%

发文量

1441

审稿时长

38 days

期刊介绍： Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.