The healing effects of moderate exercise on acetic acid-induced gastric ulcer in male rats.

Mohammad Sofiabadi, Ensiyeh Bahadoran, Fatemeh SamieeRad, Abbas Talis
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Abstract

Aim: This study aimed to evaluate the effect of moderate exercise on the healing of acetic acid-induced gastric ulcers in male rats.

Background: Gastric ulcers include benign mucosal and submucosal lesions of the gastric wall. Exercise regulates a wide range of physiological processes.

Methods: 48 male Wistar rats were randomly divided into three experimental groups (n=16 per group) as follows: control, which was left untreated after causing stomach ulcers; experimental group 1, the rats were first exercised and then received acetic acid; experimental group 2, the rats received acetic acid, and then exercised. The ulcer was caused by injecting 0.12 ml of a 60% acetic acid solution after 24 hours of not eating. The rats had a period of moderate treadmill activity either before or after the development of ulcers, lasting for a duration of 30 days. On the seventh and fourteenth days after the experiment, the rats were sacrificed, their stomach was removed, and the wound healing parameters, and wound depth were determined.

Results: Exercise before and after inducing gastric ulcers significantly decreased the depth of gastric ulcers in the experimental groups. The average number of PMN in the control group decreased in comparison to the seventh and fourteenth days following the experiment. Conversely, the number of fibroblasts, epithelialization, and new vessels increased. It seems that exercise before the appearance of ulcers has a greater effect on gastric ulcers compared to exercise after inducing gastric ulcers.

Conclusion: Exercise can prepare the gastric mucosa for forthcoming injuries, and heal gastric ulcers. Moderate aerobic exercise has significant restorative effects on gastric ulcers caused by acetic acid and is recommended.

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适度运动对醋酸诱导的雄性大鼠胃溃疡的愈合作用。
目的:本研究旨在评估适度运动对醋酸诱导的雄性大鼠胃溃疡愈合的影响:背景:胃溃疡包括胃壁粘膜和粘膜下良性病变。方法:将 48 只雄性 Wistar 大鼠随机分为以下三个实验组(每组 16 只):对照组,造成胃溃疡后不做任何处理;实验组 1,大鼠先运动后接受醋酸治疗;实验组 2,大鼠接受醋酸治疗后再运动。溃疡是在 24 小时不进食后注射 0.12 毫升 60%的醋酸溶液造成的。大鼠在溃疡发生前或发生后都有一段时间进行适度的跑步机活动,持续时间为 30 天。实验后第七天和第十四天,大鼠被处死,胃被切除,并测定伤口愈合参数和伤口深度:结果:诱导胃溃疡前后的运动明显降低了实验组胃溃疡的深度。对照组 PMN 的平均数量与实验后第七天和第十四天相比有所减少。相反,成纤维细胞、上皮细胞和新生血管的数量有所增加。看来,与诱发胃溃疡后的运动相比,溃疡出现前的运动对胃溃疡的影响更大:结论:运动能使胃黏膜为即将到来的损伤做好准备,并治愈胃溃疡。适度的有氧运动对醋酸引起的胃溃疡有明显的修复作用,值得推荐。
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2.30
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29
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