State-of-the-Art Metagenomic Sequencing and Its Role in the Diagnosis of Periprosthetic Joint Infections

IF 6.1 3区 医学 Q1 IMMUNOLOGY Infectious disease clinics of North America Pub Date : 2024-09-13 DOI:10.1016/j.idc.2024.07.011
Madiha Fida MBBS, Aaron J. Tande MD
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最先进的元基因组测序及其在假体周围关节感染诊断中的作用。
元基因组新一代测序(mNGS)越来越被认为是假体周围关节感染(PJI)的重要诊断工具。本研究回顾了 mNGS 的诊断效用,强调了它在检测病原体方面更高的灵敏度,尤其是在培养阴性和多微生物感染中。然而,这种方法的临床应用受到一些挑战的阻碍,如宿主 DNA 的普遍存在、进行大量生物信息分析的必要性以及可能导致结果误读的潜在污染。随着 mNGS 的不断发展,它在改善 PJI 管理和加强精准医学在骨科感染中的应用方面具有巨大潜力。
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来源期刊
CiteScore
8.30
自引率
0.00%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Infectious Disease Clinics of North America updates you on the latest trends in the clinical diagnosis and management of patients with infectious diseases, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in infectious disease, including clinical microbiology, compromised host infections, gastrointestinal infections, global health, hepatitis, HIV/AIDS, hospital-acquired infections, travel medicine, infection control, bacterial infections, sexually transmitted diseases, urinary tract infections, and viral infections.
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Contents Advances in the Prevention and Management of Device-Related Infections Copyright Contributors Forthcoming Issues
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