Assessment of BDNF and sialic acid levels in children with ADHD: Relation of chronotypes

IF 1.6 4区医学 Q3 DEVELOPMENTAL BIOLOGY International Journal of Developmental Neuroscience Pub Date : 2024-09-22 DOI:10.1002/jdn.10376

Esra Demirci, Melike Kevser Gul, Elif Funda Sener, Muge Gulcihan Onal, Fatma Dal

{"title":"Assessment of BDNF and sialic acid levels in children with ADHD: Relation of chronotypes","authors":"Esra Demirci, Melike Kevser Gul, Elif Funda Sener, Muge Gulcihan Onal, Fatma Dal","doi":"10.1002/jdn.10376","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Evaluation of the biomarkers and their relations with sleep in attention deficit hyperactivity disorder (ADHD) is important for understanding the impairments in cognitive functioning. In this study, we aimed to investigate the brain-derived neurotrophic factor (BDNF) and sialic acid (Sia) levels, and their possible relations with chronotypes in ADHD.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The study included 100 drug-naive children with ADHD and 74 healthy children as controls. Conners' Parent Rating Scale-Revised (CPRS-R) scores were used for the severity assessment. Morningness Eveningness Questionnaire (MEQ) was used to determine the chronotypes of participants. ELISA kits were used for the assessment of BDNF and Sia plasma levels.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Levels of BDNF and Sia were found to be statistically significantly higher in the ADHD group compared to healthy children (<i>p</i> < 0.001, <i>p</i> < 0.001, respectively). BDNF and Sia levels were found to be higher in the ADHD group with eveningness chronotype (<i>p</i> = 0.045, <i>p</i> = 0.038). The binary logistic regression model was statistically significant (<i>p</i> = 0.033), higher BDNF and Sia levels were assessed as predictive factors for the diagnosis of ADHD. Also, eveningness chronotype was found as a predictive factor of BDNF and Sia levels in ADHD.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The results indicate that BDNF and Sia levels, which are related to cognitive functions and sleep, increase with the age of ADHD. Eveningness chronotype, connected with the severity of ADHD, is related to BDNF and Sia levels. There is a need for further studies to confirm these results.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"84 8","pages":"857-866"},"PeriodicalIF":1.6000,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.10376","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Evaluation of the biomarkers and their relations with sleep in attention deficit hyperactivity disorder (ADHD) is important for understanding the impairments in cognitive functioning. In this study, we aimed to investigate the brain-derived neurotrophic factor (BDNF) and sialic acid (Sia) levels, and their possible relations with chronotypes in ADHD.

Methods

The study included 100 drug-naive children with ADHD and 74 healthy children as controls. Conners' Parent Rating Scale-Revised (CPRS-R) scores were used for the severity assessment. Morningness Eveningness Questionnaire (MEQ) was used to determine the chronotypes of participants. ELISA kits were used for the assessment of BDNF and Sia plasma levels.

Results

Levels of BDNF and Sia were found to be statistically significantly higher in the ADHD group compared to healthy children (p < 0.001, p < 0.001, respectively). BDNF and Sia levels were found to be higher in the ADHD group with eveningness chronotype (p = 0.045, p = 0.038). The binary logistic regression model was statistically significant (p = 0.033), higher BDNF and Sia levels were assessed as predictive factors for the diagnosis of ADHD. Also, eveningness chronotype was found as a predictive factor of BDNF and Sia levels in ADHD.

Conclusion

The results indicate that BDNF and Sia levels, which are related to cognitive functions and sleep, increase with the age of ADHD. Eveningness chronotype, connected with the severity of ADHD, is related to BDNF and Sia levels. There is a need for further studies to confirm these results.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

评估多动症儿童的 BDNF 和硅酸水平：时间类型的关系

目的：评估注意力缺陷多动障碍（ADHD）患者的生物标志物及其与睡眠的关系对于了解认知功能的损害非常重要。本研究旨在调查注意力缺陷多动障碍患者的脑源性神经营养因子（BDNF）和唾液酸（Sia）水平及其与时型的可能关系：研究对象包括100名未服药的多动症儿童和74名健康儿童作为对照。严重程度评估采用康纳斯家长评定量表修订版（CPRS-R）评分。晨昏问卷（MEQ）用于确定参与者的时型。ELISA试剂盒用于评估BDNF和Sia的血浆水平：结果：与健康儿童相比，多动症组的 BDNF 和 Sia 水平在统计学上明显更高（p 结论：结果表明，多动症组的 BDNF 和 Sia 水平明显高于健康儿童：结果表明，与认知功能和睡眠有关的BDNF和Sia水平随着多动症年龄的增长而增加。与多动症严重程度相关的匀夜时型与 BDNF 和 Sia 水平有关。还需要进一步的研究来证实这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.